Itgal-flox Mouse
一般名
Itgal-flox
製品ID
S-CKO-03157
背景情報
C57BL/6JCya
系統ID
CKOCMP-16408-Itgal-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Itgal-flox Mouse（カタログ番号S-CKO-03157）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Itgal-flox
系統ID
CKOCMP-16408-Itgal-B6J-VA
遺伝子名
製品ID
S-CKO-03157
遺伝子別名
(p180), Cd11a, LFA-1, LFA-1A, Ly-15, Ly-21
遺伝子別名
C57BL/6JCya
遺伝子正式名称
integrin alpha L
NCBI ID
修正
Conditional knockout
染色体
Chr 7
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000106306
NCBIトランスクリプトID
NM_001253872
ターゲット領域
Exon 5~7
有効領域の大きさ
~1.8 kb
遺伝子研究の概要
Itgal, also known as Integrin subunit alpha L, encodes an integrin component of LFA-1 and is a membrane receptor molecule widely expressed on leukocytes. It plays a key role in the interaction between white blood cells and other cells, and is involved in immune-related processes [1,2,3,5,6,7,8].
In various cancers, Itgal shows different expression patterns and associations. In non-small-cell lung cancer (NSCLC), its down-regulation in tumor tissues is associated with poor prognosis, and high Itgal expression is related to increased infiltration of CD8+ T cells, CD68+ macrophages, CD4+ T cells, and CD20+ B cells, as well as better outcomes in patients with immune checkpoint inhibitor therapy [1]. In acute myeloid leukemia, high Itgal expression is linked to poor prognosis, and it is associated with age, cytogenetic risk classifications, MDSCs, macrophages, and most immune checkpoint genes and cytokines [2]. In gastric cancer, Itgal expression is increased in cancer samples, related to poor survival, and connected with immunomodulators, chemokines, and infiltrating levels of multiple immune cell types [3]. In melanoma, it is investigated for its relationship with immune infiltration and prognosis [4]. In lung adenocarcinoma, high Itgal expression is an independent predictor of better prognosis, and it suppresses malignant progression [7]. In NSCLC, low Itgal expression is related to poorer prognosis and increased malignancy, and its co-expressed genes are associated with immune-related signaling pathways [8]. In murine low-grade glioma, Itgal/CD11A in glioma-associated microglia is critical for CX3CL1 receptor expression, CX3CL1-directed motility, and glioma mitogen production, and antibody-mediated CD11a inhibition reduces tumor growth in vivo [9].
In conclusion, Itgal is crucial in immune-cell interactions. Studies, especially those using in vivo models like the murine models in low-grade glioma research, have revealed its diverse roles in cancer development, prognosis, and immune-microenvironment regulation, providing potential directions for targeted anti-tumor strategies [9].
References：
1. Zhang, Ruihao, Zhu, Guangsheng, Li, Zaishan, Liu, Hongyu, Chen, Jun. 2024. ITGAL expression in non-small-cell lung cancer tissue and its association with immune infiltrates. In Frontiers in immunology, 15, 1382231. doi:10.3389/fimmu.2024.1382231. https://pubmed.ncbi.nlm.nih.gov/38646528/
2. Li, Ran, Wu, Xiaolu, Xue, Kai, Li, Junmin. 2022. ITGAL infers adverse prognosis and correlates with immunity in acute myeloid leukemia. In Cancer cell international, 22, 268. doi:10.1186/s12935-022-02684-x. https://pubmed.ncbi.nlm.nih.gov/35999614/
3. Zhang, Junchang, Wang, Han, Yuan, Cheng, Zhang, Changhua, He, Yulong. 2022. ITGAL as a Prognostic Biomarker Correlated With Immune Infiltrates in Gastric Cancer. In Frontiers in cell and developmental biology, 10, 808212. doi:10.3389/fcell.2022.808212. https://pubmed.ncbi.nlm.nih.gov/35399517/
4. Deng, TengFei, Wang, Chaoyong, Gao, Cong, Zhang, Qiang, Guo, Jun. 2023. ITGAL as a prognostic biomarker correlated with immune infiltrates in melanoma. In Frontiers in oncology, 13, 1181537. doi:10.3389/fonc.2023.1181537. https://pubmed.ncbi.nlm.nih.gov/37388230/
5. de Lange, Katrina M, Moutsianas, Loukas, Lee, James C, Anderson, Carl A, Barrett, Jeffrey C. 2017. Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease. In Nature genetics, 49, 256-261. doi:10.1038/ng.3760. https://pubmed.ncbi.nlm.nih.gov/28067908/
6. Lin, Fengjie, Yang, Hanxuan, Huang, Zongwei, Ye, Yunbin, Qiu, Sufang. 2024. Magnesium-related gene ITGAL: a key immunotherapy predictor and prognostic biomarker in pan-cancer. In Frontiers in pharmacology, 15, 1464830. doi:10.3389/fphar.2024.1464830. https://pubmed.ncbi.nlm.nih.gov/39605903/
7. Xiao, Zengtuan, Nian, Zhe, Zhang, Mengzhe, Liu, Zhe, Zhang, Zhenfa. . Integrated analysis highlights the significance role of ITGAL in lung adenocarcinoma. In Journal of cellular and molecular medicine, 28, e18289. doi:10.1111/jcmm.18289. https://pubmed.ncbi.nlm.nih.gov/38613346/
8. Wang, Qiang, Xiao, GuangJun, Li, Na, Jiang, Xiulin, Li, Chunhong. 2023. lncRNA PCBP1-AS1 mediated downregulation of ITGAL as a prognostic biomarker in lung adenocarcinoma. In Aging, 15, 4510-4523. doi:10.18632/aging.204756. https://pubmed.ncbi.nlm.nih.gov/37256932/
9. De Andrade Costa, Amanda, Chatterjee, Jit, Cobb, Olivia, Dahiya, Sonika, Gutmann, David H. . RNA sequence analysis reveals ITGAL/CD11A as a stromal regulator of murine low-grade glioma growth. In Neuro-oncology, 24, 14-26. doi:10.1093/neuonc/noab130. https://pubmed.ncbi.nlm.nih.gov/34043012/
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