Itgam-flox Mouse
一般名
Itgam-flox
製品ID
S-CKO-03158
背景情報
C57BL/6JCya
系統ID
CKOCMP-16409-Itgam-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Itgam-flox Mouse（カタログ番号S-CKO-03158）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Itgam-flox
系統ID
CKOCMP-16409-Itgam-B6J-VA
遺伝子名
製品ID
S-CKO-03158
遺伝子別名
CD11b/CD18, CR3, CR3A, Cd11b, F730045J24Rik, Ly-40, MAC1, Mac-1, Mac-1a
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 7
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000064821
NCBIトランスクリプトID
NM_001082960
ターゲット領域
Exon 3
有効領域の大きさ
~1.8 kb
遺伝子研究の概要
Itgam, also known as Integrin subunit alpha M, encodes the CD11b chain of the Mac-1 integrin. Mac-1 integrin is involved in mediating cell adhesion of monocytes, macrophages, and granulocytes, as well as promoting phagocytosis of complement-coated particles. It is associated with immune and inflammatory response-related pathways and is of great biological importance in maintaining normal immune function [7].
In ischemic stroke, Itgam was identified as a critical gene. Quantitative assessment showed significant overexpression in patients. Its modulation influenced the secretion of inflammatory cytokines like IL-1β, IL-6, and TNF-α, and had an impact on neuronal apoptosis, suggesting it may be a potential therapeutic target [1].
In systemic lupus erythematosus (SLE), multiple meta-analyses demonstrated a significant association between ITGAM gene polymorphism (such as rs1143679) and SLE in multiple ethnic populations. The risk allele was related to increased serum calcification propensity in SLE patients, indicating an increased cardiovascular risk [2,5,6].
In neutrophilic asthma, Itgam was identified as a critical target to distinguish it from healthy/non-NA individuals, with a strong correlation between Itgam and macrophages [3].
In diabetic nephropathy and atherosclerosis, Itgam was found to be a key gene involved in basement membrane alterations, mainly expressed within macrophages, and therapeutic strategies targeting Itgam may mitigate basement membrane lesions [4].
In Kawasaki disease, NFIL3 aggravated human coronary artery endothelial cell injury by promoting Itgam transcription [8].
In conclusion, Itgam plays essential roles in immune and inflammatory responses. Model-based research, especially studies related to gene polymorphisms, has revealed its significance in diseases such as ischemic stroke, SLE, neutrophilic asthma, diabetic nephropathy, atherosclerosis, and Kawasaki disease. Understanding Itgam's functions provides potential directions for developing therapeutic strategies for these diseases.
References：
1. Hou, Lei, Li, Zhongchen, Guo, Xiaoli, Zhang, Liyong, Li, Zefu. 2024. ITGAM is a critical gene in ischemic stroke. In Aging, 16, 6852-6867. doi:10.18632/aging.205729. https://pubmed.ncbi.nlm.nih.gov/38637126/
2. Fan, Y, Li, L-H, Pan, H-F, Sun, Z-Q, Ye, D-Q. . Association of ITGAM polymorphism with systemic lupus erythematosus: a meta-analysis. In Journal of the European Academy of Dermatology and Venereology : JEADV, 25, 271-5. doi:10.1111/j.1468-3083.2010.03776.x. https://pubmed.ncbi.nlm.nih.gov/20629846/
3. Yan, Qian, Liu, Zixing, Chen, Yujing, Zhan, Shaofeng, Huang, Xiufang. 2023. ITGAM-macrophage modulation as a potential strategy for treating neutrophilic Asthma: insights from bioinformatics analysis and in vivo experiments. In Apoptosis : an international journal on programmed cell death, 29, 393-411. doi:10.1007/s10495-023-01914-5. https://pubmed.ncbi.nlm.nih.gov/37950848/
4. Lou, Yude, Li, Peng Hui, Liu, Xiao Qi, Chen, Chen Chen, Ma, Kun Ling. 2024. ITGAM-mediated macrophages contribute to basement membrane damage in diabetic nephropathy and atherosclerosis. In BMC nephrology, 25, 72. doi:10.1186/s12882-024-03505-1. https://pubmed.ncbi.nlm.nih.gov/38413872/
5. Halfon, Matthieu, Zhang, Li, Ehirchiou, Driss, Ribi, Camillo, Busso, Nathalie. 2023. ITGAM rs1143679 Variant in Systemic Lupus Erythematosus Is Associated with Increased Serum Calcification Propensity. In Genes, 14, . doi:10.3390/genes14051105. https://pubmed.ncbi.nlm.nih.gov/37239465/
6. Lee, Young Ho, Bae, Sang-Cheol. 2014. Association between the functional ITGAM rs1143679 G/A polymorphism and systemic lupus erythematosus/lupus nephritis or rheumatoid arthritis: an update meta-analysis. In Rheumatology international, 35, 815-23. doi:10.1007/s00296-014-3156-2. https://pubmed.ncbi.nlm.nih.gov/25315704/
7. Fagerholm, S C, MacPherson, M, James, M J, Sevier-Guy, C, Lau, C S. . The CD11b-integrin (ITGAM) and systemic lupus erythematosus. In Lupus, 22, 657-63. doi:10.1177/0961203313491851. https://pubmed.ncbi.nlm.nih.gov/23753600/
8. Chen, Li, Shangguan, Zhiyang, Dong, Zeya, Ding, Yunyun, Yang, Shulong. 2023. NFIL3 aggravates human coronary artery endothelial cell injury by promoting ITGAM transcription in Kawasaki disease. In Hematology (Amsterdam, Netherlands), 28, 2277502. doi:10.1080/16078454.2023.2277502. https://pubmed.ncbi.nlm.nih.gov/37933872/
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