Tnfrsf11b-flox Mouse
一般名
Tnfrsf11b-flox
製品ID
S-CKO-04116
背景情報
C57BL/6JCya
系統ID
CKOCMP-18383-Tnfrsf11b-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tnfrsf11b-flox Mouse（カタログ番号S-CKO-04116）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tnfrsf11b-flox
系統ID
CKOCMP-18383-Tnfrsf11b-B6J-VA
遺伝子名
製品ID
S-CKO-04116
遺伝子別名
Opg, TR1, OCIF
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 15
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000079772
NCBIトランスクリプトID
NM_008764
ターゲット領域
Exon 2
有効領域の大きさ
~1.3 kb
遺伝子研究の概要
Tnfrsf11b, also known as osteoprotegerin, is a key protein involved in regulating bone resorption, with its function closely associated with the RANKL/RANK/OPG pathway. It plays a significant role in multiple biological processes, including immune response, inflammatory response, and signal transduction [1,2].
In sepsis-ARDS, TNFRSF11B levels were significantly higher compared to controls, and it was associated with vascular endothelial dysfunction, suggesting it could be a new predictive and diagnostic biomarker for vascular endothelium damage [1].
In osteoarthritic cartilage, overexpression of TNFRSF11B led to upregulation of genes related to chondrocyte to osteoblast transition, indicating it may be a driving factor in this process [2].
In gastric cancer, TNFRSF11B was highly expressed in the cytoplasm, promoting cell proliferation, migration, invasion, and inhibiting apoptosis, while activating the Wnt/β-catenin signaling pathway [3].
In obstructive sleep apnea (OSA), plasma TNFRSF11B levels were significantly higher and were associated with the presence and severity of OSA, making it a potential biomarker for premature vascular endothelial dysfunction in OSA patients [4].
In colon cancer, TNFRSF11B was identified as a prognostic factor, and its overexpression was related to lymph node invasion, pathogenic E. coli infection, and suppression of memory CD4+ T cell infiltration in the cancer microenvironment [5]. Also, TNFRSF11B polymorphisms were associated with an increased risk of short-term poor outcome in large artery atherosclerosis stroke [6].
In conclusion, Tnfrsf11b is crucial in regulating various biological processes and is significantly associated with multiple diseases, such as sepsis-ARDS, osteoarthritis, gastric cancer, OSA, colon cancer, and large artery atherosclerosis stroke. Understanding the role of Tnfrsf11b through these functional studies helps in uncovering the disease mechanisms and may potentially lead to new diagnostic and therapeutic strategies for these diseases.
References：
1. Zhang, Dong, Xu, Changjuan, Zhang, Jintao, Zhang, Jianning, Dong, Liang. 2023. Plasma TNFRSF11B as a New Predictive Inflammatory Marker of Sepsis-ARDS with Endothelial Dysfunction. In Journal of proteome research, 22, 3640-3651. doi:10.1021/acs.jproteome.3c00576. https://pubmed.ncbi.nlm.nih.gov/37851947/
2. Rodríguez Ruiz, Alejandro, Tuerlings, Margo, Das, Ankita, Ramos, Yolande F M, Meulenbelt, Ingrid. . The role of TNFRSF11B in development of osteoarthritic cartilage. In Rheumatology (Oxford, England), 61, 856-864. doi:10.1093/rheumatology/keab440. https://pubmed.ncbi.nlm.nih.gov/33989379/
3. Luan, Fengming, Li, Xiaomei, Cheng, Xiaojing, Wen, Xianzi, Ji, Jiafu. 2020. TNFRSF11B activates Wnt/β-catenin signaling and promotes gastric cancer progression. In International journal of biological sciences, 16, 1956-1971. doi:10.7150/ijbs.43630. https://pubmed.ncbi.nlm.nih.gov/32398963/
4. Wen, Wan-Wan, Ning, Yu, Zhang, Qing, Zhang, Ming, Wei, Yong-Xiang. 2018. TNFRSF11B: A potential plasma biomarker for diagnosis of obstructive sleep apnea. In Clinica chimica acta; international journal of clinical chemistry, 490, 39-45. doi:10.1016/j.cca.2018.12.017. https://pubmed.ncbi.nlm.nih.gov/30562485/
5. Zhang, Jun-Rong, Hou, Ping, Wang, Xiao-Jie, Huang, Zheng-Yuan, Chen, Xian-Qiang. 2021. TNFRSF11B Suppresses Memory CD4+ T Cell Infiltration in the Colon Cancer Microenvironment: A Multiomics Integrative Analysis. In Frontiers in immunology, 12, 742358. doi:10.3389/fimmu.2021.742358. https://pubmed.ncbi.nlm.nih.gov/34938284/
6. Wang, Mengmeng, Gu, Mengmeng, Li, Zibao, Zhang, Zhizhong, Liu, Xinfeng. 2020. TNFRSF11B polymorphisms predict poor outcome after large artery atherosclerosis stroke. In Gene, 743, 144617. doi:10.1016/j.gene.2020.144617. https://pubmed.ncbi.nlm.nih.gov/32222535/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
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