Tmsb4x-flox Mouse
一般名
Tmsb4x-flox
製品ID
S-CKO-04570
背景情報
C57BL/6JCya
系統ID
CKOCMP-19241-Tmsb4x-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tmsb4x-flox Mouse（カタログ番号S-CKO-04570）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tmsb4x-flox
系統ID
CKOCMP-19241-Tmsb4x-B6J-VA
遺伝子名
製品ID
S-CKO-04570
遺伝子別名
Tb4, Ptmb4, Tbeta4
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr X
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000112172
NCBIトランスクリプトID
NM_021278
ターゲット領域
Exon 2~3
有効領域の大きさ
~1.8 kb
遺伝子研究の概要
Tmsb4x, also known as Thymosin beta 4 X-linked, is an important regulator in immune and inflammation responses, and is involved in actin cytoskeleton remodeling [3,8]. It may play a role in various biological processes, such as cell differentiation, immune response modulation, and tumor-related processes [3,4,5,6,7,9,10].
In non-small cell lung cancer (NSCLC), higher Tmsb4x expression is associated with poorer disease-free survival (DFS) and overall survival (OS) post-surgery, and it may facilitate immune evasion by influencing dendritic cell activation [1]. In hepatocellular carcinoma (HCC), Tmsb4x promotes cell proliferation, migration, invasion, and represses ferroptosis, being involved in inflammation-associated ferroptosis [2]. In septicemia, decreased Tmsb4x expression leads to increased inflammation and reduced dendritic cell proportion, while upregulated Tmsb4x promotes mononuclear cell to dendritic cell differentiation [3]. In colorectal cancer, TMSB4X-high expression in the tumor region is a potential marker [5]. In glioma, TAGLN2 K40succ regulates TMSB4X to promote angiogenesis and tumor growth [6]. In endometriosis, circPIP5K1A accelerates progression via the miR-153-3p/TMSB4X axis [10].
In conclusion, Tmsb4x is involved in multiple biological functions including immune response, cell proliferation, and differentiation. Its dysregulation is associated with various diseases such as NSCLC, HCC, septicemia, colorectal cancer, glioma, and endometriosis. Research on Tmsb4x using in vivo models helps to understand its role in these disease processes, providing potential targets for diagnosis and treatment.
References：
1. Yang, Ze, Luo, Jihang, Zhang, Mengmei, Wang, Wei, Lu, Ligong. 2023. TMSB4X: A novel prognostic marker for non-small cell lung cancer. In Heliyon, 9, e21505. doi:10.1016/j.heliyon.2023.e21505. https://pubmed.ncbi.nlm.nih.gov/38027718/
2. Tang, Linlin, Jin, Yangli, Wang, Jinxu, Xu, Mengque, Xiang, Mingwei. 2024. TMSB4X is a regulator of inflammation-associated ferroptosis, and promotes the proliferation, migration and invasion of hepatocellular carcinoma cells. In Discover oncology, 15, 671. doi:10.1007/s12672-024-01558-0. https://pubmed.ncbi.nlm.nih.gov/39556271/
3. Liao, Yongqiang, Xiao, Ni, Wang, Xiaoming, Dai, Senhua, Wang, Guiliang. 2022. Promoting effect of Tmsb4x on the differentiation of peripheral blood mononuclear cells to dendritic cells during septicemia. In International immunopharmacology, 111, 109002. doi:10.1016/j.intimp.2022.109002. https://pubmed.ncbi.nlm.nih.gov/35932611/
4. Sun, Minxuan, Ahmad, Nafees, Zhang, Ruobing, Graw, Jochen. 2018. Crybb2 associates with Tmsb4X and is crucial for dendrite morphogenesis. In Biochemical and biophysical research communications, 503, 123-130. doi:10.1016/j.bbrc.2018.05.195. https://pubmed.ncbi.nlm.nih.gov/29864422/
5. Xiao, Jing, Yu, Xinyang, Meng, Fanlin, He, Ke, Lu, Ligong. 2024. Integrating spatial and single-cell transcriptomics reveals tumor heterogeneity and intercellular networks in colorectal cancer. In Cell death & disease, 15, 326. doi:10.1038/s41419-024-06598-6. https://pubmed.ncbi.nlm.nih.gov/38729966/
6. Zhang, Xiaoyi, Han, Jin, Fan, Di, Huang, Hailan, Gu, Yanting. 2022. Lysine-40 succinylation of TAGLN2 induces glioma angiogenesis and tumor growth through regulating TMSB4X. In Cancer gene therapy, 30, 172-181. doi:10.1038/s41417-022-00534-6. https://pubmed.ncbi.nlm.nih.gov/36131066/
7. Wang, Zengbin, Wu, Linqing, Zhou, Yu, Wei, Hong, Wang, Zhihong. 2024. Protein and metabolic profiles of tyrosine kinase inhibitors co-resistant liver cancer cells. In Frontiers in pharmacology, 15, 1394241. doi:10.3389/fphar.2024.1394241. https://pubmed.ncbi.nlm.nih.gov/38835670/
8. Fu, Wenbin, Liao, Qiao, Shi, Yu, Xu, Chunmei, Zeng, Chunyu. 2024. Transient induction of actin cytoskeletal remodeling associated with dedifferentiation, proliferation, and redifferentiation stimulates cardiac regeneration. In Acta pharmaceutica Sinica. B, 14, 2537-2553. doi:10.1016/j.apsb.2024.01.021. https://pubmed.ncbi.nlm.nih.gov/38828141/
9. Wu, Yunjian, Clark, Kimberley C, Nguyen, Elizabeth V, Taylor, Renea A, Daly, Roger J. 2022. Proteomic characterisation of prostate cancer intercellular communication reveals cell type-selective signalling and TMSB4X-dependent fibroblast reprogramming. In Cellular oncology (Dordrecht, Netherlands), 45, 1311-1328. doi:10.1007/s13402-022-00719-z. https://pubmed.ncbi.nlm.nih.gov/36169805/
10. Sun, Lin, Wei, Yan, Wang, Junli. . Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway. In Bioengineered, 12, 7104-7118. doi:10.1080/21655979.2021.1978618. https://pubmed.ncbi.nlm.nih.gov/34546850/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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