Slc31a1-flox Mouse
一般名
Slc31a1-flox
製品ID
S-CKO-05108
背景情報
C57BL/6JCya
系統ID
CKOCMP-20529-Slc31a1-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Slc31a1-flox Mouse（カタログ番号S-CKO-05108）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Slc31a1-flox
系統ID
CKOCMP-20529-Slc31a1-B6J-VA
遺伝子名
製品ID
S-CKO-05108
遺伝子別名
Ctr1, 4930445G01Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 4
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000084526
NCBIトランスクリプトID
NM_175090
ターゲット領域
Exon 3
有効領域の大きさ
~0.9 kb
遺伝子研究の概要
Slc31a1, also known as CTR1, encodes a protein that functions as a homotrimer for the uptake of dietary copper. It is an important copper transporter in the cell membrane, influencing copper absorption and thus playing a crucial role in maintaining copper homeostasis, which is essential for the activity of numerous copper-containing enzymes involved in various biological processes [4,5,7].
In a study on cardiac fibrosis, fibroblast-specific SLC31A1 deficiency enhanced mitochondrial copper depletion, augmented glycolysis, promoted fibroblast proliferation, and triggered cardiac fibrosis, suggesting that SLC31A1 is crucial in preventing mitochondrial copper depletion-related cardiac fibrosis [3].
In diabetic conditions, excessive advanced glycosylation end products (AGEs) and copper up-regulated the ATF3/SPI1/SLC31A1 signaling, disturbing copper homeostasis and promoting cuproptosis in the myocardium, indicating its role in diabetic myocardial injury [1].
High SLC31A1 expression in breast cancer was related to deregulated immune response, metabolic pathways, and predicted poor prognosis, suggesting its significance in breast cancer prognosis and immune-related processes [2].
In pan-cancer analysis, SLC31A1 expression was significantly different between tumors and normal tissues in nine cancer types, and was linked to immune cell infiltration, immune checkpoint genes, and immunotherapy markers, highlighting its potential in cancer immunotherapy [4].
In diabetic retinopathy, SLC31A1 was up-regulated, and it may be involved in the regulation of cuproptosis through the STAT1-SLC31A1 axis [6].
In cisplatin-induced acute kidney injury, SLC31A1 was up-regulated by ELF3, and its activation triggered cuproptosis through mitochondrial dysfunction, making it a potential therapeutic target to mitigate this injury [8].
In conclusion, Slc31a1 is essential for copper homeostasis. Its dysregulation is associated with various diseases such as cardiac fibrosis, diabetic complications, and cancers. Studies using gene-knockout or conditional-knockout mouse models, as well as other in-vivo studies, have revealed its critical roles in these disease-related biological processes, providing potential therapeutic targets for these conditions.
References：
1. Huo, Shengqi, Wang, Qian, Shi, Wei, Lv, Jiagao, Lin, Li. 2023. ATF3/SPI1/SLC31A1 Signaling Promotes Cuproptosis Induced by Advanced Glycosylation End Products in Diabetic Myocardial Injury. In International journal of molecular sciences, 24, . doi:10.3390/ijms24021667. https://pubmed.ncbi.nlm.nih.gov/36675183/
2. Li, Linrong, Li, Lin, Sun, Qiang. 2022. High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases. In BMC bioinformatics, 23, 350. doi:10.1186/s12859-022-04894-6. https://pubmed.ncbi.nlm.nih.gov/35996075/
3. Tu, Bin, Song, Kai, Zhou, Ze-Yu, Zhao, Jian-Yuan, Tao, Hui. 2025. SLC31A1 loss depletes mitochondrial copper and promotes cardiac fibrosis. In European heart journal, , . doi:10.1093/eurheartj/ehaf130. https://pubmed.ncbi.nlm.nih.gov/40048660/
4. Zhang, Pei, Yang, Heqi, Zhu, Kaiguo, Ye, Tinghong, Cao, Dan. 2023. SLC31A1 Identifying a Novel Biomarker with Potential Prognostic and Immunotherapeutic Potential in Pan-Cancer. In Biomedicines, 11, . doi:10.3390/biomedicines11112884. https://pubmed.ncbi.nlm.nih.gov/38001885/
5. Qi, Yue, Yao, Qingqing, Li, Xuanyan, Zhang, Wenwen, Qu, Pengpeng. 2023. Cuproptosis-related gene SLC31A1: prognosis values and potential biological functions in cancer. In Scientific reports, 13, 17790. doi:10.1038/s41598-023-44681-8. https://pubmed.ncbi.nlm.nih.gov/37853210/
6. Hu, Qiang, Zhang, Xue, Huang, Jiayang, Jiang, Bo, Sun, Dawei. 2024. The STAT1-SLC31A1 axis: Potential regulation of cuproptosis in diabetic retinopathy. In Gene, 930, 148861. doi:10.1016/j.gene.2024.148861. https://pubmed.ncbi.nlm.nih.gov/39153705/
7. Xue, Qian, Kang, Rui, Klionsky, Daniel J, Liu, Jinbao, Chen, Xin. 2023. Copper metabolism in cell death and autophagy. In Autophagy, 19, 2175-2195. doi:10.1080/15548627.2023.2200554. https://pubmed.ncbi.nlm.nih.gov/37055935/
8. Qiu, Zhimin, Liu, Qicen, Wang, Ling, Yan, Xiluan, Deng, Huangying. 2024. The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction. In Chemico-biological interactions, 393, 110943. doi:10.1016/j.cbi.2024.110943. https://pubmed.ncbi.nlm.nih.gov/38462020/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。