Tnfsf9-flox Mouse
一般名
Tnfsf9-flox
製品ID
S-CKO-06398
背景情報
C57BL/6JCya
系統ID
CKOCMP-21950-Tnfsf9-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tnfsf9-flox Mouse（カタログ番号S-CKO-06398）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tnfsf9-flox
系統ID
CKOCMP-21950-Tnfsf9-B6J-VA
遺伝子名
製品ID
S-CKO-06398
遺伝子別名
Ly63l, 4-1BBL, Cd137l, 4-1BB-L
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 17
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000039490
NCBIトランスクリプトID
NM_009404
ターゲット領域
Exon 3
有効領域の大きさ
~1.7 kb
遺伝子研究の概要
Tnfsf9, also known as CD137L/4-1BBL, is a member of the tumor necrosis factor superfamily. It functions as a T-cell co-stimulator, playing a role in cancer immunotherapy and being involved in regulating immune cell functions. It has implications in various biological processes related to the immune response and cancer [1,7].
In pancreatic cancer, Tnfsf9 expression is elevated and is associated with poor prognosis. It can promote pancreatic cancer metastasis by inducing M2 macrophage polarization through Src/FAK/p-Akt/IL-1β signaling [3], as well as through Wnt/Snail signaling [4].
In glioma, hypoxia can upregulate Tnfsf9 expression in a histone-lactylation-dependent manner, leading to M2 macrophage polarization and promoting glioma progression [2].
In hepatocellular carcinoma, Tnfsf9 expression is downregulated, and overexpression or treatment with its recombinant protein can inhibit HCC cell proliferation, migration, and invasion both in vitro and in vivo, suggesting it may be a tumor suppressor [7].
In patients with metastatic renal cell carcinoma treated with nivolumab and ipilimumab, Tnfsf9 expression may predict treatment response, with high-expression tumors showing an activated adaptive immune response [5].
Inherited Tnfsf9 deficiency in a patient led to broad Epstein-Barr virus infection with EBV+ smooth muscle tumors, highlighting the role of the CD137-CD137L (Tnfsf9) pathway in anti-EBV immunity [6].
In conclusion, Tnfsf9 has diverse functions in the immune response and cancer. Its role in promoting or inhibiting tumor progression varies depending on the cancer type. Studies on Tnfsf9, including those using relevant models, have provided insights into its functions in diseases such as cancer and viral infections, which may help develop new therapeutic strategies.
References：
1. Wu, Jiao, Wang, Yunpeng. 2022. Role of TNFSF9 bidirectional signal transduction in antitumor immunotherapy. In European journal of pharmacology, 928, 175097. doi:10.1016/j.ejphar.2022.175097. https://pubmed.ncbi.nlm.nih.gov/35714694/
2. Li, Min, Sun, Pingfeng, Tu, Binfeng, Li, Donghai, He, Wei. 2024. Hypoxia conduces the glioma progression by inducing M2 macrophage polarization via elevating TNFSF9 level in a histone-lactylation-dependent manner. In American journal of physiology. Cell physiology, 327, C487-C504. doi:10.1152/ajpcell.00124.2024. https://pubmed.ncbi.nlm.nih.gov/39010835/
3. Wu, Jiao, Wang, Yunpeng, Yang, Yichun, Jiang, Zhongxiang, Jiang, Zheng. 2021. TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling. In International immunopharmacology, 102, 108429. doi:10.1016/j.intimp.2021.108429. https://pubmed.ncbi.nlm.nih.gov/34906856/
4. Wu, Jiao, Wang, Yunpeng, Yang, Yichun, Jiang, Zhongxiang, Jiang, Zheng. 2021. TNFSF9 promotes metastasis of pancreatic cancer through Wnt/Snail signaling and M2 polarization of macrophages. In Aging, 13, 21571-21586. doi:10.18632/aging.203497. https://pubmed.ncbi.nlm.nih.gov/34517345/
5. Isoda, Bunpei, Kandori, Shuya, Sazuka, Tomokazu, Ichikawa, Tomohiko, Nishiyama, Hiroyuki. 2024. TNFSF9 Is Associated with Favorable Tumor Immune Microenvironment in Patients with Renal Cell Carcinoma Who Are Treated with the Combination Therapy of Nivolumab and Ipilimumab. In International journal of molecular sciences, 25, . doi:10.3390/ijms25137444. https://pubmed.ncbi.nlm.nih.gov/39000552/
6. Fournier, Benjamin, Hoshino, Akihiro, Bruneau, Julie, Neven, Bénédicte, Latour, Sylvain. 2022. Inherited TNFSF9 deficiency causes broad Epstein-Barr virus infection with EBV+ smooth muscle tumors. In The Journal of experimental medicine, 219, . doi:10.1084/jem.20211682. https://pubmed.ncbi.nlm.nih.gov/35657354/
7. Shen, Yu Ling, Gan, Yu, Gao, Hai Feng, Wang, Jia Dong, Tu, Hong. . TNFSF9 exerts an inhibitory effect on hepatocellular carcinoma. In Journal of digestive diseases, 18, 395-403. doi:10.1111/1751-2980.12489. https://pubmed.ncbi.nlm.nih.gov/28547807/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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