Gm94-flox Mouse

Gm94 is encoded by the mouse C5orf46 homologous gene. It is involved in the innate immune response, specifically exhibiting antimicrobial activity, which is crucial for the body's first line of defense against microbes [1].

Gm94 closely resembles AP-64, an antimicrobial peptide encoded by human C5orf46, in its antibacterial properties. AP-64 shows significant antibacterial activity against Gram-negative bacteria like Escherichia coli and Vibrio cholerae, and is also efficient in combating Escherichia coli O157:H7 infections in a mouse model. Since Gm94 has similar antibacterial properties, it can be inferred that it may play a similar role in the innate immune response in mice [1].

In conclusion, Gm94, through its antibacterial properties similar to AP-64, plays an important role in the innate immune response in mice. The study of Gm94 using mouse models helps to understand the innate immune mechanism against Gram-negative bacteria, providing insights into potential therapeutic strategies for related infectious diseases [1].