Tm4sf4-flox Mouse
一般名
Tm4sf4-flox
製品ID
S-CKO-07238
背景情報
C57BL/6JCya
系統ID
CKOCMP-229302-Tm4sf4-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tm4sf4-flox Mouse（カタログ番号S-CKO-07238）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tm4sf4-flox
系統ID
CKOCMP-229302-Tm4sf4-B6J-VA
遺伝子名
製品ID
S-CKO-07238
遺伝子別名
Iltmp
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 3
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000029377
NCBIトランスクリプトID
NM_145539
ターゲット領域
Exon 3
有効領域の大きさ
~1.5 kb
遺伝子研究の概要
Tm4sf4, a member of the transmembrane 4 superfamily, has physiological functions in regulating tissue differentiation, signal transduction pathways, cellular activation, proliferation, motility, adhesion, and angiogenesis [4]. It is involved in multiple pathways, such as the AKT pathway [1], and has been associated with the regulation of cell junction and cohesion processes [1]. Genetic models are valuable for studying Tm4sf4's role in various biological processes and diseases.
In papillary thyroid cancer (PTC), Tm4sf4 is significantly upregulated and serves as a diagnostic biomarker. Downregulation of Tm4sf4 in vitro suppressed the proliferation and metastasis of PTC cell lines while inducing apoptosis, and the AKT activator could reverse these effects, suggesting Tm4sf4 promotes PTC progression via the AKT pathway [1]. In lung and breast cancers, Tm4sf4 was identified as a potential therapeutic target through outlier analysis, and its knockdown suppressed the growth of lung cancer cell lines [2]. In hepatocellular carcinoma, Tm4sf4 was highly expressed, and the lncRNA ST8SIA6-AS1 regulated its expression through the miR-651-5p/Tm4sf4 axis, affecting cancer cell proliferation and migration [3]. In radiation-resistant lung adenocarcinoma cells, Tm4sf4 was highly expressed, activating cell growth, migration, and invasion via IGF1-induced IGF1R activation [5]. In colorectal cancer, Tm4sf4 was the downstream target of TYMS, and its overexpression increased the migration and invasion of CRC cells by regulating EMT and CD133 expression [6]. Adenovirus-mediated delivery of siRNA targeting Tm4sf4 attenuated liver cancer cell growth in vitro and in vivo [7].
In conclusion, Tm4sf4 plays crucial roles in the progression of multiple cancers, including papillary thyroid cancer, lung cancer, breast cancer, hepatocellular carcinoma, and colorectal cancer. Studies using gene knockdown or knockout-like models (such as siRNA-mediated knockdown) have revealed its oncogenic functions, making it a potential target for cancer diagnosis and treatment.
References：
1. Lin, Lizhi, Wen, Jialiang, Xu, Tiansheng, Si, Yuhao. 2024. TM4SF4 is a diagnostic biomarker accelerating progression of papillary thyroid cancer via AKT pathway. In Cancer biology & therapy, 25, 2424570. doi:10.1080/15384047.2024.2424570. https://pubmed.ncbi.nlm.nih.gov/39497261/
2. Jung, Kyungsoo, Choi, Joon-Seok, Koo, Beom-Mo, Oh, Doo-Yi, Choi, Yoon-La. 2020. TM4SF4 and LRRK2 Are Potential Therapeutic Targets in Lung and Breast Cancers through Outlier Analysis. In Cancer research and treatment, 53, 9-24. doi:10.4143/crt.2020.434. https://pubmed.ncbi.nlm.nih.gov/32972043/
3. Mou, Yanjie, Ding, Xiaoming. 2022. LncRNA ST8SIA6-AS1 facilitates hepatocellular carcinoma progression by governing miR-651-5p/TM4SF4 axis. In Anti-cancer drugs, 33, 741-751. doi:10.1097/CAD.0000000000001326. https://pubmed.ncbi.nlm.nih.gov/35946523/
4. Rahim, Nur Syafiqah, Wu, Yuan Seng, Sim, Maw Shin, Sekar, Mahendran, Guad, Rhanye Mac. 2023. Three Members of Transmembrane-4-Superfamily, TM4SF1, TM4SF4, and TM4SF5, as Emerging Anticancer Molecular Targets against Cancer Phenotypes and Chemoresistance. In Pharmaceuticals (Basel, Switzerland), 16, . doi:10.3390/ph16010110. https://pubmed.ncbi.nlm.nih.gov/36678607/
5. Choi, Soo-Im, Kim, Seo-Yeon, Lee, Jaeha, Cho, Eun-Wie, Kim, In-Gyu. . TM4SF4 overexpression in radiation-resistant lung carcinoma cells activates IGF1R via elevation of IGF1. In Oncotarget, 5, 9823-37. doi:. https://pubmed.ncbi.nlm.nih.gov/25344917/
6. Zhang, Fen, Ye, Jiecheng, Guo, Wenjing, Wang, Liyuan, Han, Anjia. 2022. TYMS-TM4SF4 axis promotes the progression of colorectal cancer by EMT and upregulating stem cell marker. In American journal of cancer research, 12, 1009-1026. doi:. https://pubmed.ncbi.nlm.nih.gov/35411242/
7. Wang, Leiming, Feng, Jian, Da, Liang, Li, Zaiping, Zhao, Mujun. 2013. Adenovirus-mediated delivery of siRNA targeting TM4SF4 attenuated liver cancer cell growth in vitro and in vivo. In Acta biochimica et biophysica Sinica, 45, 213-9. doi:10.1093/abbs/gms115. https://pubmed.ncbi.nlm.nih.gov/23296076/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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