Csde1-flox Mouse

Csde1, also known as cold shock domain containing E1, is an RNA-binding protein that plays a key role in translational reprogramming. It can promote or repress RNA translation and influence RNA abundance [2]. Csde1 is involved in multiple biological pathways, such as the miRNA-mediated gene regulation pathway and Wnt/β-catenin signaling pathway, and is important for biological processes like hematopoiesis, erythrocyte development, and may be relevant in cancer development [1,2,3,4]. Genetic models are valuable for studying Csde1's function.

In zebrafish, depletion of csde1 in genetic mutants and morphants impaired the production of hematopoietic stem and progenitor cells (HSPCs), as Csde1 regulates HSPC generation by modulating Wnt/β-catenin signaling activity, specifically by binding to ctnnb1 mRNAs and regulating their translation [4]. In mouse models, depletion of CSDE1 in primary mouse keratinocytes led to senescence bypass, cell immortalization, and tumor formation, indicating its role as a potential tumor suppressor in oncogene-induced senescence (OIS) [5].

In conclusion, Csde1 is a crucial regulator in translational reprogramming and is involved in multiple biological processes. Model-based research, especially the use of gene-knockout models in zebrafish and mice, has revealed its roles in hematopoiesis and oncogene-induced senescence, providing insights into related disease mechanisms such as cancer development.