Tnfsf13b-flox Mouse
一般名
Tnfsf13b-flox
製品ID
S-CKO-08322
背景情報
C57BL/6JCya
系統ID
CKOCMP-24099-Tnfsf13b-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tnfsf13b-flox Mouse（カタログ番号S-CKO-08322）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tnfsf13b-flox
系統ID
CKOCMP-24099-Tnfsf13b-B6J-VA
遺伝子名
製品ID
S-CKO-08322
遺伝子別名
BAFF, BLyS, TALL1, THANK, zTNF4, TALL-1, Tnlg7a, TNFSF20, D8Ertd387e
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 8
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000207792
NCBIトランスクリプトID
NM_033622
ターゲット領域
Exon 1~2
有効領域の大きさ
~2.6 kb
遺伝子研究の概要
Tnfsf13b, also known as the gene encoding B-cell activating factor (BAFF) (tumor necrosis factor ligand superfamily member 13B), is a key regulator in the immune system. BAFF is crucial for the survival of transitional and mature B cells [3]. It is involved in maintaining the B-cell pool and humoral immunity, and its overexpression can lead to autoimmunity in mice, with elevated levels detected in the sera of autoimmune patients [3,6].
Polymorphisms in the Tnfsf13b gene are related to the susceptibility of primary Sjögren's syndrome (pSS). The SNP rs12583006 was significantly related to pSS susceptibility in pSS patients, and polymorphisms in this gene were related to vulnerability to pSS among both pSS patients and healthy controls [1]. In rheumatoid arthritis (RA), the rs9514828 T allele and the TAT haplotype were associated with an increased risk of developing the disease, and the rs9514828 (- 871 C > T) polymorphism was associated with increased gene expression in RA patients [2]. In apical periodontitis, the rs9514828 (- 871 C > T) polymorphism was associated with primary apical periodontitis (pAP) susceptibility, with the TT genotype and T allele associated with an increased risk of pAP, while the minor allele T decreased the risk of secondary AP (sAP) [4]. Also, in severe adenovirus pneumonia in pediatric patients, the protein level of Tnfsf13b in plasma was enhanced, and it showed potential as an inflammatory indicator to predict severe cases [5].
In conclusion, Tnfsf13b is essential for B-cell survival and humoral immunity. Genetic polymorphisms of Tnfsf13b are associated with various autoimmune and inflammatory diseases such as pSS, RA, and apical periodontitis. The elevation of Tnfsf13b protein levels in plasma may serve as an indicator for severe adenovirus pneumonia in pediatric patients. Understanding the role of Tnfsf13b through these genetic-based disease associations helps in further exploring the mechanisms of these diseases and potentially developing new treatment strategies.
References：
1. Zheng, Anhao, Hu, Naiwen, Xu, Jing, Bai, Yanyan, Sun, Hongsheng. . Associations between TNFSF13B polymorphisms and primary Sjögren's syndrome susceptibility in primary Sjögren's syndrome patients: A meta-analysis. In Immunity, inflammation and disease, 11, e1103. doi:10.1002/iid3.1103. https://pubmed.ncbi.nlm.nih.gov/38156381/
2. Santillán-López, Enrique, Muñoz-Valle, José Francisco, Oregon-Romero, Edith, Cerpa-Cruz, Sergio, Palafox-Sánchez, Claudia Azucena. 2022. Analysis of TNFSF13B polymorphisms and BAFF expression in rheumatoid arthritis and primary Sjögren's syndrome patients. In Molecular genetics & genomic medicine, 10, e1950. doi:10.1002/mgg3.1950. https://pubmed.ncbi.nlm.nih.gov/35411715/
3. Mackay, Fabienne, Schneider, Pascal, Rennert, Paul, Browning, Jeffrey. 2001. BAFF AND APRIL: a tutorial on B cell survival. In Annual review of immunology, 21, 231-64. doi:. https://pubmed.ncbi.nlm.nih.gov/12427767/
4. Cruz, Alvaro, Gascón, Luis Gerardo, Palafox-Sánchez, Claudia Azucena, Mejía-Flores, Rocío, Salazar-Camarena, Diana Celeste. 2022. TNFSF13B rs9514828 gene polymorphism and soluble B cell activating factor levels: Association with apical periodontitis. In International endodontic journal, 56, 419-431. doi:10.1111/iej.13879. https://pubmed.ncbi.nlm.nih.gov/36508294/
5. Fan, Huifeng, Lu, Bingtai, Cao, Can, Wu, Minhao, Lu, Gen. 2021. Plasma TNFSF13B and TNFSF14 Function as Inflammatory Indicators of Severe Adenovirus Pneumonia in Pediatric Patients. In Frontiers in immunology, 11, 614781. doi:10.3389/fimmu.2020.614781. https://pubmed.ncbi.nlm.nih.gov/33542721/
6. Samy, Eileen, Wax, Stephen, Huard, Bertrand, Hess, Henry, Schneider, Pascal. . Targeting BAFF and APRIL in systemic lupus erythematosus and other antibody-associated diseases. In International reviews of immunology, 36, 3-19. doi:10.1080/08830185.2016.1276903. https://pubmed.ncbi.nlm.nih.gov/28215100/
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