Or2j3-flox Mouse

Or2j3, an olfactory receptor gene, is involved in smell perception and has been found to have additional functions beyond the olfactory system. It plays roles in various signaling pathways, such as those related to intracellular calcium and cAMP regulation [1,3,4]. Its biological importance extends to processes like cell proliferation, wound healing, and cytokine secretion, which are relevant to disease-related pathophysiological processes [1,4].

In lung epithelial cells, stimulation of Or2j3 with cinnamaldehyde reduced interleukin-8 (IL-8) secretion, cell proliferation, and wound healing, while increasing cAMP levels, suggesting its potential as a drug target for non-type 2 inflammation in lung diseases [1]. In non-small-cell lung cancer (NSCLC) cell line A549, activation of Or2j3 by helional induced apoptosis, inhibited cell proliferation and migration [4]. Also, genetic variation in Or2j3 is associated with the ability to detect the "grassy" smelling odor, cis-3-hexen-1-ol [2].

In conclusion, Or2j3 is involved in multiple biological processes, including smell perception, cell growth regulation, and cytokine secretion. Its role in lung diseases, especially non-type 2 inflammation and NSCLC, highlights its potential significance in disease treatment. The findings from studies on Or2j3 contribute to understanding the complex relationship between olfactory receptors and disease pathophysiology [1,2,4].