Slc27a2-flox Mouse
一般名
Slc27a2-flox
製品ID
S-CKO-09608
背景情報
C57BL/6NCya
系統ID
CKOCMP-26458-Slc27a2-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Slc27a2-flox Mouse（カタログ番号S-CKO-09608）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Slc27a2-flox
系統ID
CKOCMP-26458-Slc27a2-B6N-VA
遺伝子名
製品ID
S-CKO-09608
遺伝子別名
VLCS, Vlac, FATP2, Vlacs, ACSVL1
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conditional knockout
染色体
Chr 2
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000061491
NCBIトランスクリプトID
NM_011978
ターゲット領域
Exon 4
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
Slc27a2, also known as Fatty acid transport protein 2 (FATP2), is crucial for fatty acid transportation and metabolism. It is associated with the peroxisome proliferator-activated receptors (PPARs) pathway, which is closely related to fatty acid metabolism and tumor progression [1]. Slc27a2 also plays a role in lipid biosynthesis [2]. Genetic models, such as gene knockout or conditional knockout mouse models, can be used to study its functions.
In various cancer types, studies have shown its significant impact. In colorectal cancer, it is overexpressed and mediates fatty acid uptake and beta-oxidation through nongenic crosstalk regulation of the PPARs pathway [1]. In differentiated thyroid carcinoma, its upregulation promotes tumor proliferation and migration, affecting cell proliferation and differentiation via the MAPK pathway and proto-oncogene C-FOS [2]. In hematological tumors, it is a potential immune biomarker, being involved in the immune process of diffuse large B-cell lymphoma (DLBCL) and acute myeloid leukemia (AML) through different immune cell correlations and pathways [3]. In ovarian cancer, its down-regulation in primary tissues correlates with chemo-resistance, and up-regulation sensitizes cells to cisplatin via the SLC27A2-miR-411-ABCG2 pathway [4]. In renal cancer, its down-regulation in clinical specimens predicts poor prognosis, and up-regulation suppresses the proliferation and invasion by down-regulating CDK3-mediated epithelial-mesenchymal transition (EMT) [5]. In acute lymphoblastic leukemia, high expression predicts unfavorable prognosis and promotes inhibitory immune infiltration, with knockdown in vitro inhibiting cell proliferation and affecting the Akt pathway [6]. In neuroblastoma, MYCN directly upregulates Slc27a2, and its genetic depletion impairs tumor survival [7]. In lung cancer stem cells, reduced Slc27a2 induces cisplatin resistance by negatively regulating Bmi1-ABCG2 signaling [8].
In conclusion, Slc27a2 is essential for fatty acid-related metabolism and significantly impacts multiple disease conditions, especially various cancers. Studies using gene knockout or conditional knockout mouse models (if applicable) could potentially further elucidate its functions in these disease areas, providing insights into potential therapeutic targets.
References：
1. Shang, Kun, Ma, Nina, Che, Juanjuan, Sun, Haolin, Cao, Bangwei. 2023. SLC27A2 mediates FAO in colorectal cancer through nongenic crosstalk regulation of the PPARs pathway. In BMC cancer, 23, 335. doi:10.1186/s12885-023-10816-3. https://pubmed.ncbi.nlm.nih.gov/37041476/
2. Feng, Kaixiang, Ma, Runsheng, Li, Hongqiang, Liu, Zhen, Yin, Detao. 2021. Upregulated SLC27A2/FATP2 in differentiated thyroid carcinoma promotes tumor proliferation and migration. In Journal of clinical laboratory analysis, 36, e24148. doi:10.1002/jcla.24148. https://pubmed.ncbi.nlm.nih.gov/34854499/
3. Wang, Yi, Chen, Xue, Li, Yun, Jin, Fengbo, Li, Hongxia. 2024. SLC27A2 is a potential immune biomarker for hematological tumors and significantly regulates the cell cycle progression of diffuse large B-cell lymphoma. In BMC medical genomics, 17, 105. doi:10.1186/s12920-024-01853-3. https://pubmed.ncbi.nlm.nih.gov/38664735/
4. Chen, F D, Chen, H H, Ke, S C, Zheng, L R, Zheng, X Y. 2018. SLC27A2 regulates miR-411 to affect chemo-resistance in ovarian cancer. In Neoplasma, 65, 915-924. doi:10.4149/neo_2018_180122N48. https://pubmed.ncbi.nlm.nih.gov/30334452/
5. Xu, Ning, Xiao, Wen, Meng, Xiangui, Zhang, Xiaoping, Yang, Hongmei. 2022. Up-regulation of SLC27A2 suppresses the proliferation and invasion of renal cancer by down-regulating CDK3-mediated EMT. In Cell death discovery, 8, 351. doi:10.1038/s41420-022-01145-8. https://pubmed.ncbi.nlm.nih.gov/35927229/
6. Lu, Lihua, Li, Jiazheng, Zheng, Yongzhi, Hu, Jianda, Chen, Yanxin. 2024. High expression of SLC27A2 predicts unfavorable prognosis and promotes inhibitory immune infiltration in acute lymphoblastic leukemia. In Translational oncology, 45, 101952. doi:10.1016/j.tranon.2024.101952. https://pubmed.ncbi.nlm.nih.gov/38640787/
7. Tao, Ling, Mohammad, Mahmoud A, Milazzo, Giorgio, Coarfa, Cristian, Barbieri, Eveline. 2022. MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma. In Nature communications, 13, 3728. doi:10.1038/s41467-022-31331-2. https://pubmed.ncbi.nlm.nih.gov/35764645/
8. Su, Jie, Wu, Shifei, Tang, Wei, Zhou, Hui, Guo, Tao. 2015. Reduced SLC27A2 induces cisplatin resistance in lung cancer stem cells by negatively regulating Bmi1-ABCG2 signaling. In Molecular carcinogenesis, 55, 1822-1832. doi:10.1002/mc.22430. https://pubmed.ncbi.nlm.nih.gov/26513225/
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