Rbms1-flox Mouse

RBMS1, short for RNA binding motif single strand interacting protein 1, is an RNA-binding protein. It is involved in multiple biological processes, such as translational control, mRNA stability regulation, and is associated with pathways like ferroptosis, autocrine IL-6/JAK2/STAT3 signaling, and immune-related pathways. Its functions have significant implications for cancer development, cellular senescence, and other biological conditions, making genetic models crucial for its study.

In cancer research, depletion of RBMS1 has shown multiple beneficial effects. In lung cancer, it inhibits cancer progression by promoting ferroptosis through translational control of SLC7A11 [1]. In gastric cancer, silencing RBMS1 can block its metastasis-promoting effect via autocrine IL-6/JAK2/STAT3 signaling [2]. In triple-negative breast cancer, loss of RBMS1 enhances anti-tumor immunity by enabling PD-L1 checkpoint blockade [3]. In glioblastoma, RBMS1 interference inhibits cell malignant progression and promotes ferroptosis [4]. In colorectal cancer, inhibiting the RBMS1/PRNP axis improves oxaliplatin chemoresistance by enhancing ferroptosis [5].

In conclusion, RBMS1 plays a complex role in various biological processes, especially in cancer. Model-based research, including gene knockout or conditional knockout mouse models, has revealed its significance in promoting or suppressing cancer progression through different mechanisms, providing potential therapeutic targets for multiple cancer types.