Il21r-flox Mouse
一般名
Il21r-flox
製品ID
S-CKO-12542
背景情報
C57BL/6JCya
系統ID
CKOCMP-60504-Il21r-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Il21r-flox Mouse（カタログ番号S-CKO-12542）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Il21r-flox
系統ID
CKOCMP-60504-Il21r-B6J-VA
遺伝子名
製品ID
S-CKO-12542
遺伝子別名
NILR
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 7
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000033000
NCBIトランスクリプトID
NM_021887
ターゲット領域
Exon 3
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
Il21r, the interleukin-21 receptor, is a crucial component in the immune-related cytokine signaling pathway. It binds to interleukin-21, a cytokine mainly produced by CD4 T cells. This interaction is involved in multiple biological processes such as promoting effector functions and memory differentiation of CD8 T cells, and is associated with the regulation of the Th2 immune response, as well as playing roles in cell survival and differentiation in the immune system [2,3,4].
In breast cancer, IL21R hypomethylation was identified as a potential biomarker to distinguish benign and malignant breast tumours. BC patients showed significant IL21R hypomethylation compared to those with benign tumours, and this hypomethylation was more pronounced in ER-negative, PR-negative, and triple-negative tumours. The methylation of IL21R had efficient discriminatory power in differentiating between these tumour types [1].
In multiple myeloma, bone marrow CD14+ cells from patients with multiple myeloma over-expressed IL21R, which was independent of interleukin-21 presence, and this over-expression increased osteoclast formation. Inhibition of interleukin-21 receptor signaling suppressed osteoclast differentiation from these cells [5].
In metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma, IL-21R signaling promoted the disease by inducing immunosuppressive IgA+ B cells. High IL-21R expression in HCC patients was associated with poor relapse-free survival, advanced TNM stage, and severe steatosis, and ablation of IL-21R impeded hepatocarcinogenesis [6].
In conclusion, Il21r plays essential roles in immune-related processes and is associated with various diseases including breast cancer, multiple myeloma, and hepatocellular carcinoma. Research using different models has revealed its significance in disease-related biological mechanisms, such as its potential as a biomarker in breast cancer diagnosis and its role in promoting tumour-related processes in multiple myeloma and hepatocellular carcinoma. These findings contribute to our understanding of disease pathogenesis and may offer new directions for disease diagnosis and treatment.
References：
1. Zang, Zishan, Yin, Yifei, Liu, Chunlan, Li, Hong, Yang, Rongxi. 2024. IL21R hypomethylation as a biomarker for distinguishing benign and malignant breast tumours. In Epigenetics, 19, 2352683. doi:10.1080/15592294.2024.2352683. https://pubmed.ncbi.nlm.nih.gov/38723244/
2. Ren, Heather M, Lukacher, Aron E, Rahman, Ziaur S M, Olsen, Nancy J. 2021. New developments implicating IL-21 in autoimmune disease. In Journal of autoimmunity, 122, 102689. doi:10.1016/j.jaut.2021.102689. https://pubmed.ncbi.nlm.nih.gov/34224936/
3. Carneiro, Valdirene Leão, da Silva, Hugo Bernardino Ferreira, Queiroz, Gerson de Almeida, Cooper, Philip J, Figueiredo, Camila Alexandrina. 2021. WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides. In Frontiers in immunology, 12, 622051. doi:10.3389/fimmu.2021.622051. https://pubmed.ncbi.nlm.nih.gov/33692795/
4. Sun, Weiwei, Gao, Ce, Hartana, Ciputra Adijaya, Yu, Xu G, Lichterfeld, Mathias. 2023. Phenotypic signatures of immune selection in HIV-1 reservoir cells. In Nature, 614, 309-317. doi:10.1038/s41586-022-05538-8. https://pubmed.ncbi.nlm.nih.gov/36599977/
5. Bolzoni, Marina, Ronchetti, Domenica, Storti, Paola, Aversa, Franco, Giuliani, Nicola. 2017. IL21R expressing CD14+CD16+ monocytes expand in multiple myeloma patients leading to increased osteoclasts. In Haematologica, 102, 773-784. doi:10.3324/haematol.2016.153841. https://pubmed.ncbi.nlm.nih.gov/28057743/
6. Xie, Ying, Huang, Yu, Li, Zhi-Yong, Yin, Zhinan, Lin, Xue-Jia. 2024. Interleukin-21 receptor signaling promotes metabolic dysfunction-associated steatohepatitis-driven hepatocellular carcinoma by inducing immunosuppressive IgA+ B cells. In Molecular cancer, 23, 95. doi:10.1186/s12943-024-02001-2. https://pubmed.ncbi.nlm.nih.gov/38720319/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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