Derl3-flox Mouse
一般名
Derl3-flox
製品ID
S-CKO-14802
背景情報
C57BL/6JCya
系統ID
CKOCMP-70377-Derl3-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Derl3-flox Mouse（カタログ番号S-CKO-14802）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Derl3-flox
系統ID
CKOCMP-70377-Derl3-B6J-VA
遺伝子名
製品ID
S-CKO-14802
遺伝子別名
1810006I20Rik, 1810063P04Rik, IZP6, derlin-3
遺伝子別名
C57BL/6JCya
遺伝子正式名称
Der1-like domain family, member 3
NCBI ID
修正
Conditional knockout
染色体
Chr 10
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000009236
NCBIトランスクリプトID
NM_024440
ターゲット領域
Exon 1~7
有効領域の大きさ
~2.6 kb
遺伝子研究の概要
DERL3, also known as Derlin-3, is a key gene in the endoplasmic reticulum-associated protein degradation pathway. It is involved in the degradation of misfolded lumenal glycoproteins induced by endoplasmic reticulum (ER) stress [7].
DERL3 has been studied in multiple disease contexts. In colorectal cancer, its low expression in cancer tissues is linked to a high rate of lymphatic and distant metastasis. Overexpression of DERL3 in HT29 cells suppresses their proliferative, migratory, and invasive capacities, likely through negatively regulating MYCN level [1].
In gastric cancer, DERL3 acts as a tumor suppressor, with its promoter methylation correlated with tumor clinical features. Genes co-expressed with DERL3 are involved in adaptive immune response, T cell activation, etc. [3].
In nasopharyngeal carcinoma, Epstein-Barr virus latent membrane protein 1 represses DERL3 via DNA methylation, and DERL3 knockdown leads to increased cell proliferation, migration, and invasion [5].
In lung adenocarcinoma, DERL3 is upregulated in carcinoma tissues, and high-expressed patients have a worse response to chemotherapy and immunotherapy. It is positively correlated with B cell activation and unfolded protein response (UPR) [6].
In renal clear cell carcinoma, elevated DERL3 expression indicates a poor prognosis [4].
In rheumatoid arthritis, DERL3 is up-regulated in fibroblast-like synoviocytes of RA patients, and TNF-α-induced DERL3 expression promotes inflammation through activating the NF-κB signaling pathway [2].
In conclusion, DERL3 plays crucial roles in various biological processes and diseases. In cancer, it often acts as a tumor suppressor or is associated with prognosis. In rheumatoid arthritis, it contributes to inflammation. Studies on DERL3 help understand disease mechanisms and may provide potential therapeutic targets.
References：
1. Yu, Fubing, Mou, Bo, Sheng, Juan, Qin, Xiangxin, Yu, Jiaman. 2020. DERL3 suppresses colorectal cancer metastasis through negatively regulating MYCN level. In Minerva medica, 114, 316-322. doi:10.23736/S0026-4806.20.06657-4. https://pubmed.ncbi.nlm.nih.gov/32538588/
2. Geng, Manman, Xu, Ke, Meng, Liesu, Zhu, Wenhua, Lu, Shemin. 2020. Up-regulated DERL3 in fibroblast-like synoviocytes exacerbates inflammation of rheumatoid arthritis. In Clinical immunology (Orlando, Fla.), 220, 108579. doi:10.1016/j.clim.2020.108579. https://pubmed.ncbi.nlm.nih.gov/32866644/
3. Li, Yongyuan, Liu, Hongjie, Chen, Hekai, Cai, Xuejun, He, Xianghui. 2019. DERL3 functions as a tumor suppressor in gastric cancer. In Computational biology and chemistry, 84, 107172. doi:10.1016/j.compbiolchem.2019.107172. https://pubmed.ncbi.nlm.nih.gov/31862624/
4. Fan, Weining, Ran, Lingxiang, Wang, Lexin, Chi, Hao. 2024. The elevated DERL3 expression indicates poor prognosis in renal clear cell carcinoma. In Asian journal of surgery, , . doi:10.1016/j.asjsur.2024.06.115. https://pubmed.ncbi.nlm.nih.gov/39034257/
5. Kondo, Satoru, Okabe, Atsushi, Nakagawa, Takuya, Yoshizaki, Tomokazu, Kaneda, Atsushi. 2022. Repression of DERL3 via DNA methylation by Epstein-Barr virus latent membrane protein 1 in nasopharyngeal carcinoma. In Biochimica et biophysica acta. Molecular basis of disease, 1869, 166598. doi:10.1016/j.bbadis.2022.166598. https://pubmed.ncbi.nlm.nih.gov/36372158/
6. Lin, Lanlan, Lin, Guofu, Lin, Hai, Xu, Yuan, Zeng, Yiming. 2022. Integrated profiling of endoplasmic reticulum stress-related DERL3 in the prognostic and immune features of lung adenocarcinoma. In Frontiers in immunology, 13, 906420. doi:10.3389/fimmu.2022.906420. https://pubmed.ncbi.nlm.nih.gov/36275646/
7. Lopez-Serra, Paula, Marcilla, Miguel, Villanueva, Alberto, Albar, Juan Pablo, Esteller, Manel. 2014. A DERL3-associated defect in the degradation of SLC2A1 mediates the Warburg effect. In Nature communications, 5, 3608. doi:10.1038/ncomms4608. https://pubmed.ncbi.nlm.nih.gov/24699711/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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