Prxl2a-flox Mouse
一般名
Prxl2a-flox
製品ID
S-CKO-14860
背景情報
C57BL/6NCya
系統ID
CKOCMP-70564-Prxl2a-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Prxl2a-flox Mouse（カタログ番号S-CKO-14860）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Prxl2a-flox
系統ID
CKOCMP-70564-Prxl2a-B6N-VA
遺伝子名
製品ID
S-CKO-14860
遺伝子別名
Adrx, Pamm, Fam213a, 5730469M10Rik
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conditional knockout
染色体
Chr 14
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000022317
NCBIトランスクリプトID
NM_027464
ターゲット領域
Exon 3
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
Prxl2a, also known as peroxiredoxin like 2A, is an antioxidant protein. It protects cells from oxidative stress and may be involved in multiple biological processes related to redox regulation [1]. Oxidative stress is associated with various disease conditions, highlighting the importance of Prxl2a in maintaining cellular homeostasis.
In oral squamous cell carcinoma (OSCC), miR-125b downregulation leads to Prxl2a upregulation, protecting tumor cells from oxidative stress. Exogenous miR-125b expression in OSCC cells increases oxidative stress and drug sensitivity, similar to Prxl2a knockout, indicating an miR-125b-Prxl2a regulatory axis in OSCC pathogenesis [1].
In endometrial cancer, a prognostic signature including Prxl2a was established. Knockdown of Prxl2a significantly inhibited the proliferation and colony formation of Ishikawa and AN3CA cells, and suppressed xenograft growth [2].
In kidney renal clear cell carcinoma, Prxl2a was identified as one of six antioxidant genes significantly correlated with patient outcome, and high-risk patients (related to the six-gene signature including Prxl2a) had poorer prognosis [3].
In an Alzheimer's mouse model treated with cyanidin 3-O-glucoside, Prxl2a was among the upregulated antioxidant genes, suggesting its role in the antioxidant mechanism of the treatment [4].
In a mouse model of snakebite envenoming, Prxl2a was predicted as a biomarker sensitive to antivenom treatment, indicating its potential role in the pathophysiological changes after envenoming [5].
In conclusion, Prxl2a plays a crucial role in protecting cells from oxidative stress. Through gene-knockout or knockdown models in different disease conditions such as OSCC, endometrial cancer, kidney renal clear cell carcinoma, Alzheimer's disease, and snakebite envenoming, its functions in promoting tumor cell survival, affecting prognosis, and being involved in antioxidant and pathophysiological processes have been revealed. These findings contribute to a better understanding of the molecular mechanisms underlying these diseases and may provide potential therapeutic targets.
References：
1. Chen, Yi-Fen, Wei, Yun-Yen, Yang, Cheng-Chieh, Chang, Kuo-Wei, Lin, Shu-Chun. 2019. miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. In Redox biology, 22, 101140. doi:10.1016/j.redox.2019.101140. https://pubmed.ncbi.nlm.nih.gov/30785086/
2. Yu, Jing, Yao, Hong-Wen, Liu, Ting-Ting, Ma, Sai, Wu, Ling-Ying. 2022. Comprehensive Analysis and Experimental Validation of a Novel Estrogen/Progesterone-Related Prognostic Signature for Endometrial Cancer. In Journal of personalized medicine, 12, . doi:10.3390/jpm12060914. https://pubmed.ncbi.nlm.nih.gov/35743699/
3. Ren, Xueting, Ma, Li, Wang, Nan, Kang, Huafeng, Zhou, Zhangjian. 2021. Antioxidant Gene Signature Impacts the Immune Infiltration and Predicts the Prognosis of Kidney Renal Clear Cell Carcinoma. In Frontiers in genetics, 12, 721252. doi:10.3389/fgene.2021.721252. https://pubmed.ncbi.nlm.nih.gov/34490047/
4. Jaiswal, Varun, Park, Miey, Lee, Hae-Jeung. 2021. Comparative Transcriptome Analysis of the Expression of Antioxidant and Immunity Genes in the Spleen of a Cyanidin 3-O-Glucoside-Treated Alzheimer's Mouse Model. In Antioxidants (Basel, Switzerland), 10, . doi:10.3390/antiox10091435. https://pubmed.ncbi.nlm.nih.gov/34573067/
5. Bala, Auwal A, Bedraoui, Anas, El Mejjad, Salim, Daouda, Tariq, Galan, Jacob A. 2025. Bioinformatics-Guided Identification and Quantification of Biomarkers of Crotalus atrox Envenoming and Its Neutralization by Antivenom. In Molecular & cellular proteomics : MCP, 24, 100956. doi:10.1016/j.mcpro.2025.100956. https://pubmed.ncbi.nlm.nih.gov/40147718/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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グローバル由来:
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