Smim24-flox Mouse
一般名
Smim24-flox
製品ID
S-CKO-15414
背景情報
C57BL/6JCya
系統ID
CKOCMP-72273-Smim24-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Smim24-flox Mouse（カタログ番号S-CKO-15414）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Smim24-flox
系統ID
CKOCMP-72273-Smim24-B6J-VA
遺伝子名
製品ID
S-CKO-15414
遺伝子別名
2210404O07Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 10
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000105322
NCBIトランスクリプトID
NM_001099917
ターゲット領域
Exon 1~3
有効領域の大きさ
~1.4 kb
遺伝子研究の概要
Smim24, whose full name is Small Integral Membrane Protein 24, is a gene with its function yet to be fully elucidated. However, its involvement in multiple biological contexts has been noted. It may be associated with various cellular processes considering its appearance in different tissue-related transcriptomic studies [3,4].
Smim24 has been identified in multiple prognostic models. In clear-cell renal-cell carcinoma (ccRCC), it is part of a prognostic model related to activated dendritic cells, and the model can predict outcomes in advanced ccRCC patients, and is associated with tumor progression, tumor mutation burden, immune cell infiltration, and immunotherapy outcomes [1]. It is also part of a prognostic model in ccRCC related to chemokine-related genes, where high-risk group patients with higher expression of Smim24 and other genes have a poorer prognosis [2]. Additionally, in a study on clear cell renal carcinoma, Smim24 was screened to construct a risk model for predicting prognosis and drug sensitivity [7].
In a transcriptomic analysis of human α-cells, the expression of Smim24 was altered in α-pseudoislets in a time-dependent manner [3]. In a hepatocellular carcinoma cell line Li-7, Smim24 was among the genes overexpressed in cancer stem cell-like CD13+CD166-cells which maintain tumorigenicity [4]. In a study on longitudinal gene expression changes in cognitively intact older adults, Smim24 was among the genes showing differential expression in APOE4 carriers, potentially implicating disrupted immune system, protein removal, and metabolism [5]. In a case of 19p13.3 microduplication syndrome, Smim24 was within a duplicated region in a patient with nephrotic syndrome and other clinical phenotypes [6].
In conclusion, Smim24 seems to be involved in the prognosis and biological processes related to multiple diseases, especially in renal-related carcinomas. Its appearance in various prognostic models and differential expression in disease-related cell types or genetic conditions suggest its importance in understanding disease mechanisms, which may provide new insights for disease treatment and prediction [1,2,3,4,5,6,7].
References：
1. Ye, Zijian, Zhang, Yifan, Xu, Jialiang, Wang, Meijiao, Xie, Biao. 2024. Integrating Bulk and Single-Cell RNA-Seq Data to Identify Prognostic Features Related to Activated Dendritic Cells in Clear-Cell Renal-Cell Carcinoma. In International journal of molecular sciences, 25, . doi:10.3390/ijms25179235. https://pubmed.ncbi.nlm.nih.gov/39273185/
2. Meng, Yuhao, Zhang, Chen, Fu, Tongfei, Wu, Junsong, Zhan, Yongli. 2024. RETRACTED: Exploring the tumor microenvironment: Chemokine-related genes and immunotherapy/chemotherapy response in clear-cell renal cell carcinoma. In Environmental toxicology, 40, E74-E91. doi:10.1002/tox.24190. https://pubmed.ncbi.nlm.nih.gov/38488671/
3. Kahraman, Sevim, Shibue, Kimitaka, De Jesus, Dario F, Choudhary, Amit, Kulkarni, Rohit N. 2023. Fluorescein-based sensors to purify human α-cells for functional and transcriptomic analyses. In eLife, 12, . doi:10.7554/eLife.85056. https://pubmed.ncbi.nlm.nih.gov/37732504/
4. Seyama, Yusuke, Sudo, Kazuhiro, Hirose, Suguru, Tsuchiya, Kiichiro, Nakamura, Yukio. 2023. Identification of a gene set that maintains tumorigenicity of the hepatocellular carcinoma cell line Li-7. In Human cell, 36, 2074-2086. doi:10.1007/s13577-023-00967-7. https://pubmed.ncbi.nlm.nih.gov/37610679/
5. Luckett, Emma S, Zielonka, Magdalena, Kordjani, Amine, Cleynen, Isabelle, Vandenberghe, Rik. 2023. Longitudinal APOE4- and amyloid-dependent changes in the blood transcriptome in cognitively intact older adults. In Alzheimer's research & therapy, 15, 121. doi:10.1186/s13195-023-01242-5. https://pubmed.ncbi.nlm.nih.gov/37438770/
6. Sun, Wenjie, Yan, Hong, Sun, Mengxin, Wang, Jie, Li, Kunxia. 2025. Expanding the clinical spectrum of 19p13.3 microduplication syndrome: a case report highlighting nephrotic syndrome and literature review. In BMC pediatrics, 25, 70. doi:10.1186/s12887-025-05394-1. https://pubmed.ncbi.nlm.nih.gov/39875952/
7. Chang, Qinzheng, Zhao, Shuo, Sun, Jiajia, Fan, Yidong, Liu, Jikai. 2025. Identification of a novel prognostic and therapeutic prediction model in clear cell renal carcinoma based on Renin-angiotensin system related genes. In Frontiers in endocrinology, 16, 1521940. doi:10.3389/fendo.2025.1521940. https://pubmed.ncbi.nlm.nih.gov/40099255/
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