Ocstamp-flox Mouse
一般名
Ocstamp-flox
製品ID
S-CKO-16069
背景情報
C57BL/6JCya
系統ID
CKOCMP-74614-Ocstamp-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Ocstamp-flox Mouse（カタログ番号S-CKO-16069）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Ocstamp-flox
系統ID
CKOCMP-74614-Ocstamp-B6J-VA
遺伝子名
製品ID
S-CKO-16069
遺伝子別名
OC-STAMP, 4833422F24Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 2
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000029213
NCBIトランスクリプトID
NM_029021
ターゲット領域
Exon 2
有効領域の大きさ
~1.9 kb
遺伝子研究の概要
Ocstamp, short for osteoclast stimulatory transmembrane protein, is a key molecule in osteoclast multinucleation, a hallmark of osteoclast maturation. Along with DC-STAMP, it is considered a "master fusogen" in this process, enabling bone resorption by facilitating the reconstruction of the cytoskeleton to form the actin ring and ruffled border [1,4]. It is also involved in other cellular processes like epithelial-mesenchymal transition (EMT) and cellular senescence in alveolar type II epithelial cells, and may play a role in fibrotic processes related to silicosis [2,3,6].
In studies, overexpression of Ocstamp in MLE-12 cells (mouse alveolar type II epithelial cells) promoted EMT, endoplasmic reticulum (ER) stress, and cellular senescence. Knockdown of Ocstamp inhibited cellular senescence in these cells transfected with pcmv6-Ocstamp [3]. In silicosis, treatment with Ocstamp siRNA alleviated the progression of the disease in mice, suggesting its potential as a diagnostic and therapeutic target [6]. Also, molecules like resveratrol, luteolin, PKM2 activators, and glucan from baker's yeast were found to affect osteoclast differentiation and Ocstamp expression. Resveratrol inhibited doxorubicin-induced osteoclast differentiation and reduced Oc-stamp expression [5]. Luteolin alleviated cadmium-induced bone damage by reducing Oc-STAMP expression [7]. PKM2 activators inhibited osteoclast differentiation and affected osteoclast precursor cell fusion by downregulating Oc-STAMP [8]. Glucan from baker's yeast suppressed RANKL-induced osteoclastogenesis and downregulated Oc-stamp [9].
In conclusion, Ocstamp is crucial for osteoclast multinucleation and has implications in various disease-related cellular processes such as EMT, cellular senescence, and silicosis fibrosis. Studies using gene knockdown models, like siRNA-mediated Ocstamp inhibition in mice, have provided valuable insights into its role in these disease conditions, highlighting its potential as a biomarker and therapeutic target for silicosis and a key factor in understanding osteoclast-related bone diseases [3,6,8].
References：
1. Kodama, Joe, Kaito, Takashi. 2020. Osteoclast Multinucleation: Review of Current Literature. In International journal of molecular sciences, 21, . doi:10.3390/ijms21165685. https://pubmed.ncbi.nlm.nih.gov/32784443/
2. Geng, F, Cai, Y H, Zhao, Y, Xu, H, Yang, F. . [The mechanism of OC-STAMP overexpression induced actin cytoskeleton remodeling in promoting epithelial-mesenchymal transition in the alveolar type Ⅱ epithelial cell]. In Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases, 41, 801-807. doi:10.3760/cma.j.cn121094-20221009-00479. https://pubmed.ncbi.nlm.nih.gov/38073205/
3. Li, Tian, Yang, Xin-Yu, Xu, Ding-Jie, Yang, Fang, Xu, Hong. 2021. OC-STAMP Overexpression Drives Lung Alveolar Epithelial Cell Type II Senescence in Silicosis. In Oxidative medicine and cellular longevity, 2021, 4158495. doi:10.1155/2021/4158495. https://pubmed.ncbi.nlm.nih.gov/34426759/
4. Miyamoto, Takeshi. 2013. STATs and macrophage fusion. In JAK-STAT, 2, e24777. doi:10.4161/jkst.24777. https://pubmed.ncbi.nlm.nih.gov/24069561/
5. Poudel, Sunil, Martins, Gil, Cancela, M Leonor, Gavaia, Paulo J. 2022. Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation. In International journal of molecular sciences, 23, . doi:10.3390/ijms232315160. https://pubmed.ncbi.nlm.nih.gov/36499492/
6. Wu, Jing, Zhang, Bingyu, Du, Wei, Ke, Yanyan, Yi, Xue. 2025. OC-STAMP is a potential biomarker and therapeutic target for Silicosis: an exploratory investigation. In Journal of translational medicine, 23, 214. doi:10.1186/s12967-024-05981-3. https://pubmed.ncbi.nlm.nih.gov/39985047/
7. Tong, Xishuai, Fu, Xiaohui, Gong, Anqing, Gu, Jianhong, Liu, Zongping. . Effect of Luteolin on cadmium-inhibited bone growth via suppressing osteoclastogenesis in laying chickens. In Journal of animal science, 103, . doi:10.1093/jas/skaf033. https://pubmed.ncbi.nlm.nih.gov/39921628/
8. Cai, Cong, Jiang, Jiawei, Li, Song, Zhao, Libo, Xiao, Jun. 2025. PKM2 regulates osteoclastogenesis by affecting osteoclast precursor cell fusion via downregulation of OC-STAMP and DC-STAMP. In The Journal of biological chemistry, 301, 108439. doi:10.1016/j.jbc.2025.108439. https://pubmed.ncbi.nlm.nih.gov/40122175/
9. Hara, Shiika, Nagai-Yoshioka, Yoshie, Yamasaki, Ryota, Nishihara, Tatsuji, Ariyoshi, Wataru. 2020. Dectin-1-mediated suppression of RANKL-induced osteoclastogenesis by glucan from baker's yeast. In Journal of cellular physiology, 236, 5098-5107. doi:10.1002/jcp.30217. https://pubmed.ncbi.nlm.nih.gov/33305824/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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