Dpp3-flox Mouse
一般名
Dpp3-flox
製品ID
S-CKO-16181
背景情報
C57BL/6JCya
系統ID
CKOCMP-75221-Dpp3-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Dpp3-flox Mouse（カタログ番号S-CKO-16181）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Dpp3-flox
系統ID
CKOCMP-75221-Dpp3-B6J-VA
遺伝子名
製品ID
S-CKO-16181
遺伝子別名
DPP III, 4930533O14Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 19
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000025851
NCBIトランスクリプトID
NM_133803
ターゲット領域
Exon 6
有効領域の大きさ
~0.6 kb
遺伝子研究の概要
Dpp3, also known as dipeptidyl peptidase 3 and NEMP3 (neuron bound extracellular metallopeptidase 3), is a zinc-dependent peptidase [3]. It contains the unique HEXXGH catalytic sequence and is mainly cytoplasmic, associated with the degradation of oligopeptides having 4 to 10 amino acid residues [1]. Dpp3 is involved in various cellular activities and pathophysiological mechanisms, such as the renin-angiotensin system (related to blood pressure regulation), pain signaling, inflammation, and oxidative stress [1].
In cardiovascular diseases, Dpp3 serves as a biomarker for poor prognosis in patients, with plasma Dpp3 concentration levels closely linked to the mortality of diseases like cardiogenic shock and heart failure [1]. In cardiogenic shock patients, higher circulating Dpp3 (cDPP3) plasma concentration was associated with the need for ventilation, pulmonary hypertension, and reduced stroke volume, suggesting its potential to predict disease progression [6].
In cancer, Dpp3 is upregulated in breast, esophageal, and colorectal cancers. In breast cancer, Dpp3 promotes tumorigenesis by stabilizing FASN and promoting lipid synthesis [2]. In esophageal carcinoma, Dpp3 depletion led to reduced cell proliferation, migration, and enhanced apoptosis, inhibiting tumour growth and invasion in a xenograft model [4]. In colorectal cancer, down-regulation of Dpp3 inhibited cell proliferation, colony formation, migration, and promoted apoptosis in vitro and reduced tumorigenicity in vivo, and it was found to target CDK1 [5].
In conclusion, Dpp3 plays significant roles in both cardiovascular diseases and cancer. In cardiovascular diseases, it has potential as a biomarker for cardiogenic shock progression. In cancer, it acts as an oncogene-like factor promoting tumour development in multiple cancer types. These findings from functional studies, including those resembling gene-knockout-like effects in cell models, help in understanding its biological functions and its potential as a therapeutic target in these disease areas.
References：
1. Ye, Peng, Duan, Wei, Leng, Yue-Qi, Tan, Xing, Wang, Wei-Zhong. 2022. DPP3: From biomarker to therapeutic target of cardiovascular diseases. In Frontiers in cardiovascular medicine, 9, 974035. doi:10.3389/fcvm.2022.974035. https://pubmed.ncbi.nlm.nih.gov/36312232/
2. Fu, Xiaoyu, Li, Xu, Wang, Weixing, Li, Juanjuan. . DPP3 promotes breast cancer tumorigenesis by stabilizing FASN and promoting lipid synthesis. In Acta biochimica et biophysica Sinica, 56, 805-818. doi:10.3724/abbs.2024054. https://pubmed.ncbi.nlm.nih.gov/38655619/
3. Kropotova, Ekaterina S, Pavlova, Ekaterina N, Naryzhny, Stanislav N, Mosevitsky, Mark I. 2022. Dipeptidylamino-tripeptidylcarboxypeptidase NEMP3 and DPP3 (DPP III) are the same protein. In Biochemical and biophysical research communications, 616, 110-114. doi:10.1016/j.bbrc.2022.05.078. https://pubmed.ncbi.nlm.nih.gov/35653825/
4. Liu, Jing-Kun, Abudula, Abulizi, Yang, Hai-Tao, Tulahong, Aisiker, Eli, Maynur. 2022. DPP3 expression promotes cell proliferation and migration in vitro and tumour growth in vivo, which is associated with poor prognosis of oesophageal carcinoma. In Oncology reports, 49, . doi:10.3892/or.2022.8446. https://pubmed.ncbi.nlm.nih.gov/36382663/
5. Tong, Yixin, Huang, Yuan, Zhang, Yuchao, Xia, Zhongsheng, Lai, Dongming. 2021. DPP3/CDK1 contributes to the progression of colorectal cancer through regulating cell proliferation, cell apoptosis, and cell migration. In Cell death & disease, 12, 529. doi:10.1038/s41419-021-03796-4. https://pubmed.ncbi.nlm.nih.gov/34023852/
6. Innelli, Pasquale, Lopizzo, Teresa, Paternò, Giovanni, Pittella, Giuseppe, Paternoster, Gianluca. 2023. Dipeptidyl Amino-Peptidase 3 (DPP3) as an Early Marker of Severity in a Patient Population with Cardiogenic Shock. In Diagnostics (Basel, Switzerland), 13, . doi:10.3390/diagnostics13071350. https://pubmed.ncbi.nlm.nih.gov/37046568/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
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