Cep43-flox Mouse

Cep43, a gene with no common aliases mentioned in the provided references, plays a crucial role in cilia-related processes. Cilia are important organelles for cell signaling and locomotion, constructed via intraflagellar transport (IFT). Cep43 is involved in the assembly of IFT complexes into IFT trains for ciliary entry [1].

Structural modeling indicates that the N-terminal domain of Cep43 forms a homo-dimer. It anchors at the subdistal appendages of cilia through a direct interaction with CEP350. A long linker separates this N-terminal domain from the C-terminal domain, which captures CEP19 above the subdistal appendages and close to the distal appendages. This architecture provides a framework for how RabL2 is anchored at the ciliary base via CEP19 before being handed over to IFT trains for ciliary entry [1].

In conclusion, Cep43 is essential for the proper structural organization and function of cilia, specifically in the processes related to the anchoring and transfer of components for ciliary entry. Although no KO/CKO mouse models were mentioned in the references, the structural insights into Cep43's role in ciliary processes contribute to our understanding of cilia-associated biological functions and potentially related diseases.