Mir382-flox Mouse

Mir382 is a microRNA that has been shown to play regulatory roles in various physiological processes such as osteogenic differentiation, hematopoietic stem cell differentiation, normal hematopoiesis, and liver progenitor cell differentiation [4]. It is also involved in multiple signaling pathways, for example, it was found to target the PTEN-Akt axis, regulating hepatocyte proliferation and cell growth during liver regeneration [7].

Deregulation of Mir382 has been widely reported in different cancers. In many oncogenesis studies, Mir382 downregulation was observed in cancers, and it exerted a suppressor impact on the malignant phenotype of cancer cells both in vitro and in vivo [4]. In urogenital cancers, curcumin exerts its anticancer effects in part by downregulating oncogenic microRNAs including Mir382 [3]. Additionally, Mir382 is among the miRNAs that interact with DSCAM-AS1, an lncRNA with pathogenic roles in multiple cancers [1].

In colorectal cancer, Mir382 is overexpressed in cancer-associated fibroblasts (CAFs), and these miRNAs can influence the spread, invasiveness, and chemoresistance in neighboring tumor cells via paracrine signaling [2]. It is also involved in the development of osteosarcoma stem cells, which are associated with tumor initiation, metastasis, recurrence, and drug resistance [6]. In papillary thyroid cancer, the expression level of Mir382-5p was found to be different in patients compared to healthy controls [8]. Moreover, in high-fat-diet-induced obese mice, liraglutide treatment decreased the expression of Mir382, which was negatively related to the browning of white adipose tissue [5].

In conclusion, Mir382 plays a crucial role in various biological processes and diseases, especially in cancer. Its deregulation is associated with different cancer types, and its involvement in multiple cellular and signaling pathways makes it a potential diagnostic and therapeutic marker. Studies on Mir382, including those using in vivo models, contribute to a better understanding of its functions and its potential in cancer treatment [1,2,3,4,5,6,7,8].