Fam167b-flox Mouse

Fam167b, along with Fam167A, belongs to the FAM167 gene family. These genes are evolutionarily conserved and not homologous to other annotated genes. The proteins they encode, DIORA-1 (from Fam167A) and DIORA-2 (presumably from Fam167b), are characterized by a high content of intrinsic disorder [1].

The reference focuses more on Fam167A in rheumatic diseases. It found that autoimmune risk genotypes within the FAM167A-BLK locus lead to increased expression of Fam167A. DIORA-1 has high expression in the lung, specifically in bronchial epithelium and alveolar macrophages with an endosomal localization pattern, suggesting a potential role in rheumatic disease pathogenesis [1].

In summary, while the reference mainly explored Fam167A, the FAM167 gene family including Fam167b shows conserved features and the encoded proteins' disordered nature might be relevant. The study of Fam167b in relation to rheumatic diseases could potentially provide more insights into disease mechanisms, similar to how the exploration of Fam167A has pointed to its role in the pathogenesis of rheumatic diseases [1].