Nrgn-flox Mouse
一般名
Nrgn-flox
製品ID
S-CKO-18181
背景情報
C57BL/6JCya
系統ID
CKOCMP-64011-Nrgn-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Nrgn-flox Mouse（カタログ番号S-CKO-18181）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Nrgn-flox
系統ID
CKOCMP-64011-Nrgn-B6J-VB
遺伝子名
製品ID
S-CKO-18181
遺伝子別名
NG, RC3, Pss1, NG/RC3, 0710001B06Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 9
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000065668
NCBIトランスクリプトID
NM_022029
ターゲット領域
Exon 2~3
有効領域の大きさ
~1.2 kb
遺伝子研究の概要
Nrgn, or neurogranin, is a small brain protein expressed in various telencephalic areas. It plays an essential role in synaptic plasticity by regulating the availability of calmodulin (CaM) [4].
In glioma, NRGN acts as a tumor suppressor. LINC00641 can upregulate NRGN by absorbing miR-4262, thus inhibiting glioma cell proliferation [1]. Also, in glioblastoma, lncRNA RBPMS-AS1 promotes NRGN transcription through the miR-301a-3p/CAMTA1 axis, enhancing the radiosensitivity of glioblastoma [5].
In patients with mild traumatic brain injury, serum NRGN levels are significantly higher in those with traumatic intracranial lesions compared to those without, suggesting its potential as a diagnostic biomarker [2]. Moreover, a single-nucleotide polymorphism (rs12807809) in the NRGN gene is associated with abnormal Papez circuit function in schizophrenia patients [3]. Additionally, in the Han Chinese population, polymorphisms in NRGN are associated with schizophrenia, major depressive disorder, and bipolar disorder [8].
In Alzheimer's disease, NRGN levels in neuron-derived extracellular vesicles in plasma are elevated, potentially serving as a biomarker [7]. In adults with obstructive sleep apnea without dementia, higher levels of NRGN in neuron-derived exosomes are associated with cognitive impairment [6].
In conclusion, Nrgn is crucial for synaptic plasticity. Its study in various disease models has revealed its significance in glioma, traumatic brain injury, schizophrenia, mental disorders, Alzheimer's disease, and obstructive sleep apnea-related cognitive impairment. These findings contribute to understanding the disease mechanisms and may offer new diagnostic and therapeutic targets.
References：
1. Yang, Jinghui, Yu, Duo, Liu, Xueshibojie, Changyong, E, Yu, Shan. 2020. LINC00641/miR-4262/NRGN axis confines cell proliferation in glioma. In Cancer biology & therapy, 21, 758-766. doi:10.1080/15384047.2020.1776581. https://pubmed.ncbi.nlm.nih.gov/32543324/
2. Çevik, Serdar, Özgenç, Mustafa Murat, Güneyk, Ahmet, Hanımoğlu, Hakan, Kaynar, Mehmet Yaşar. 2019. NRGN, S100B and GFAP levels are significantly increased in patients with structural lesions resulting from mild traumatic brain injuries. In Clinical neurology and neurosurgery, 183, 105380. doi:10.1016/j.clineuro.2019.105380. https://pubmed.ncbi.nlm.nih.gov/31234132/
3. Zhang, Yifan, Gong, Xiaohong, Yin, Zhiyang, Wang, Fei, Tang, Yanqing. 2019. Association between NRGN gene polymorphism and resting-state hippocampal functional connectivity in schizophrenia. In BMC psychiatry, 19, 108. doi:10.1186/s12888-019-2088-5. https://pubmed.ncbi.nlm.nih.gov/30953482/
4. Rueda-García, Valentina, Rondón-Barragán, Iang Schroniltgen. 2023. Molecular Characterization of Neurogranin (NRGN) Gene from Red‑Bellied Pacu (Piaractus brachypomus). In Molecular neurobiology, 61, 2620-2630. doi:10.1007/s12035-023-03700-5. https://pubmed.ncbi.nlm.nih.gov/37922064/
5. Li, Wenyang, Cui, Yan, Ma, Wenjia, Cai, Yang, Jiang, Yugang. 2021. LncRNA RBPMS-AS1 promotes NRGN transcription to enhance the radiosensitivity of glioblastoma through the microRNA-301a-3p/CAMTA1 axis. In Translational oncology, 15, 101282. doi:10.1016/j.tranon.2021.101282. https://pubmed.ncbi.nlm.nih.gov/34800915/
6. Li, Mengfan, Shen, Tengqun, Yao, Ran, Li, Zhenguang, Zhang, Jinbiao. 2024. Mitochondrial dysfunction is associated with cognitive impairment in adults with OSA without dementia. In Sleep medicine, 119, 234-243. doi:10.1016/j.sleep.2024.04.035. https://pubmed.ncbi.nlm.nih.gov/38704871/
7. Eitan, Erez, Thornton-Wells, Tricia, Elgart, Katya, Smith, Daniel G, Kapogiannis, Dimitrios. 2023. Synaptic proteins in neuron-derived extracellular vesicles as biomarkers for Alzheimer's disease: novel methodology and clinical proof of concept. In Extracellular vesicles and circulating nucleic acids, 4, 133-150. doi:10.20517/evcna.2023.13. https://pubmed.ncbi.nlm.nih.gov/37842184/
8. Wen, Zujia, Chen, Jianhua, Khan, Raja Amjad Waheed, Li, Wenjin, Shi, Yongyong. 2016. Polymorphisms in NRGN are associated with schizophrenia, major depressive disorder and bipolar disorder in the Han Chinese population. In Journal of affective disorders, 194, 180-7. doi:10.1016/j.jad.2016.01.034. https://pubmed.ncbi.nlm.nih.gov/26828755/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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