Serpind1-flox Mouse
一般名
Serpind1-flox
製品ID
S-CKO-18213
背景情報
C57BL/6JCya
系統ID
CKOCMP-15160-Serpind1-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Serpind1-flox Mouse（カタログ番号S-CKO-18213）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Serpind1-flox
系統ID
CKOCMP-15160-Serpind1-B6J-VB
遺伝子名
製品ID
S-CKO-18213
遺伝子別名
HC-II, HCII, Hcf2
遺伝子別名
C57BL/6JCya
遺伝子正式名称
serine (or cysteine) peptidase inhibitor, clade D, member 1
NCBI ID
修正
Conditional knockout
染色体
Chr 16
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000023450
NCBIトランスクリプトID
NM_008223
ターゲット領域
Exon 3~5
有効領域の大きさ
~4.7 kb
遺伝子研究の概要
Serpind1, also known as heparin cofactor II, is a member of the serine protease inhibitor family. It is involved in modulating coagulation and can interact with glycosaminoglycans (GAGs) to enhance protease inhibition [3]. Some serpins utilize GAGs like heparin and heparan sulfate to achieve maximal protease inhibition, and Serpind1 is one of them [3].
In epithelial ovarian cancer, Serpind1 expression is significantly elevated. High Serpind1 expression is associated with poor prognosis. It promotes cancer cell proliferation, migration, invasion, G1-to-S phase transition, and epithelial-mesenchymal transition, while inhibiting apoptosis through promoting phosphorylation in the PI3K/AKT pathway [1].
In papillary thyroid carcinoma, Serpind1 was identified as a biomarker related to SUMOylation, with gene set enrichment analysis showing its involvement in immune-related pathways [2].
In glaucoma, Serpind1 is significantly upregulated and may play a vital role in glaucoma occurrences, associated with eye transparency decrease and glucose metabolism [4].
In systemic sclerosis-associated pulmonary hypertension, higher levels of Serpind1 were associated with better survival in patients [5].
In melanoma, proteins including Serpind1 in plasma-derived extracellular vesicles were identified as relevant in differentiating between disease stages [6].
In intrahepatic cholestasis of pregnancy, Serpind1 expression levels were remarkably lower in patients compared to healthy pregnant controls, and it had a negative correlation with total bile acid [7].
In atherosclerosis, miR-155 induced by polycyclic aromatic hydrocarbons downregulates Serpind1, accelerating the development of arteriosclerosis [8].
In conclusion, Serpind1 is an important serine protease inhibitor involved in multiple biological processes and diseases. Its role in modulating coagulation through GAG-binding is well-established. In various cancers, glaucoma, pregnancy-related conditions, and atherosclerosis, Serpind1 shows differential expression patterns and impacts disease progression. Understanding Serpind1's function provides insights into disease mechanisms and potential therapeutic targets.
References：
1. Guo, Qian, Zhu, Liancheng, Wang, Caixia, Li, Xiao, Lin, Bei. 2019. SERPIND1 Affects the Malignant Biological Behavior of Epithelial Ovarian Cancer via the PI3K/AKT Pathway: A Mechanistic Study. In Frontiers in oncology, 9, 954. doi:10.3389/fonc.2019.00954. https://pubmed.ncbi.nlm.nih.gov/31637210/
2. Li, Xiang, Ding, Zigang, Tong, Yun. 2024. Identification of SUMOylation-related biomarkers in papillary thyroid carcinoma. In Cancer cell international, 24, 149. doi:10.1186/s12935-024-03323-3. https://pubmed.ncbi.nlm.nih.gov/38671425/
3. Rein, Chantelle M, Desai, Umesh R, Church, Frank C. . Serpin-glycosaminoglycan interactions. In Methods in enzymology, 501, 105-37. doi:10.1016/B978-0-12-385950-1.00007-9. https://pubmed.ncbi.nlm.nih.gov/22078533/
4. Liu, Xiaoyan, Liu, Xiang, Wang, Ying, Xu, Jiyu, Sun, Wei. 2021. Proteome Characterization of Glaucoma Aqueous Humor. In Molecular & cellular proteomics : MCP, 20, 100117. doi:10.1016/j.mcpro.2021.100117. https://pubmed.ncbi.nlm.nih.gov/34214668/
5. Mismetti, Valentine, Delavenne, Xavier, Montani, David, Bertoletti, Laurent, Cottin, Vincent. 2023. Proteomic biomarkers for survival in systemic sclerosis-associated pulmonary hypertension. In Respiratory research, 24, 273. doi:10.1186/s12931-023-02578-0. https://pubmed.ncbi.nlm.nih.gov/37936223/
6. Bollard, S M, Howard, J, Casalou, C, McCann, A, Potter, S M. 2024. Proteomic and metabolomic profiles of plasma-derived Extracellular Vesicles differentiate melanoma patients from healthy controls. In Translational oncology, 50, 102152. doi:10.1016/j.tranon.2024.102152. https://pubmed.ncbi.nlm.nih.gov/39405606/
7. Chen, Lingyan, Li, Jingyang, You, Yilan, Xiao, Jianping, Zhang, Yan. 2023. Secreted proteins in plasma and placenta as novel non-invasive biomarkers for intrahepatic cholestasis of pregnancy: A case-control study. In Heliyon, 9, e21616. doi:10.1016/j.heliyon.2023.e21616. https://pubmed.ncbi.nlm.nih.gov/38027820/
8. He, Xiao-Nan, Xin, Jin-Yuan, Zhan, Jin-Liang, Zhang, Xiao-Ling, Bai, Ying-Chen. 2021. Polycyclic aromatic hydrocarbons induce endothelial injury through miR-155 to promote atherosclerosis. In Environmental and molecular mutagenesis, 62, 409-421. doi:10.1002/em.22454. https://pubmed.ncbi.nlm.nih.gov/34331478/
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