Zkscan1-flox Mouse
一般名
Zkscan1-flox
製品ID
S-CKO-18616
背景情報
C57BL/6JCya
系統ID
CKOCMP-74570-Zkscan1-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Zkscan1-flox Mouse（カタログ番号S-CKO-18616）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Zkscan1-flox
系統ID
CKOCMP-74570-Zkscan1-B6J-VB
遺伝子名
製品ID
S-CKO-18616
遺伝子別名
KOX18, PHZ-37, ZNF139, 5930429A01Rik, 9130423L19Rik, 9230118B16Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conditional knockout
染色体
Chr 5
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000019660
NCBIトランスクリプトID
NM_133906
ターゲット領域
Exon 3
有効領域の大きさ
~1.2 kb
遺伝子研究の概要
ZKSCAN1, a zinc finger family gene, is expressed in both linear and circular (circZKSCAN1) forms of RNA [5]. It has been linked to multiple biological processes and disease conditions. ZKSCAN1 has recently been identified as a regulator of histone mRNA polyadenylation-mediated inflammation, acting as a novel RNA binding protein [6]. It has also been found to interact with ATXN1, with altered expression of its target genes observed in SCA1 mice and patient-derived iNeurons, suggesting its potential contribution to spinocerebellar ataxia type 1 pathogenesis [7].
In cancer research, studies on circZKSCAN1, a circular RNA derived from ZKSCAN1, have shown diverse functions. In hepatocellular carcinoma (HCC), circZKSCAN1-encoded peptide circZKSaa suppresses HCC via degradation of mTOR, inhibiting the PI3K/AKT/mTOR pathway, and could be a biomarker and therapeutic target [1]. Additionally, both ZKSCAN1 mRNA and circZKSCAN1 inhibit HCC cell growth, migration, and invasion through different signaling pathways, with ZKSCAN1 mRNA mainly regulating cellular metabolism and circZKSCAN1 mediating cancer-related signaling pathways [5]. In lung adenocarcinoma, circ-ZKSCAN1 promotes tumorigenesis and cisplatin resistance by regulating the miR-185-5p/TAGLN2 axis [2]. In non-small cell lung cancer, circ-ZKSCAN1 promotes progression by acting as a sponge of miR-330-5p to increase FAM83A expression and inactivate the MAPK signaling pathway [3]. Conversely, in bladder cancer, circZKSCAN1 inhibits cancer progression through the miR-1178-3p/p21 axis and can serve as a prognostic factor of recurrence [4].
In conclusion, ZKSCAN1 and its circular RNA counterpart play significant roles in multiple biological processes, especially in cancer and neurodegenerative diseases. Research on ZKSCAN1, particularly through studies on its circular RNA forms in cancer models, has provided insights into disease mechanisms, highlighting its potential as a biomarker and therapeutic target in cancer treatment, and also suggesting its importance in understanding the pathogenesis of spinocerebellar ataxia type 1.
References：
1. Song, Runjie, Ma, Shuoqian, Xu, Jiajia, Li, Guangming, Li, Xiangdong. 2023. A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR. In Molecular cancer, 22, 16. doi:10.1186/s12943-023-01719-9. https://pubmed.ncbi.nlm.nih.gov/36691031/
2. Yu, Nanbin, Gong, Huaijun, Chen, Wei, Peng, Weixing. 2023. CircRNA ZKSCAN1 promotes lung adenocarcinoma progression by miR-185-5p/TAGLN2 axis. In Thoracic cancer, 14, 1467-1476. doi:10.1111/1759-7714.14889. https://pubmed.ncbi.nlm.nih.gov/37105934/
3. Wang, Yuanyong, Xu, Rongjian, Zhang, Dongyang, Wang, Jianxun, Jiao, Wenjie. . Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression. In Translational lung cancer research, 8, 862-875. doi:10.21037/tlcr.2019.11.04. https://pubmed.ncbi.nlm.nih.gov/32010565/
4. Bi, Junming, Liu, Hongwei, Dong, Wei, Huang, Jian, Lin, Tianxin. 2019. Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence. In Molecular cancer, 18, 133. doi:10.1186/s12943-019-1060-9. https://pubmed.ncbi.nlm.nih.gov/31481066/
5. Yao, Zhicheng, Luo, Jingyan, Hu, Kunpeng, Liu, Bo, Yang, Yang. 2017. ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways. In Molecular oncology, 11, 422-437. doi:10.1002/1878-0261.12045. https://pubmed.ncbi.nlm.nih.gov/28211215/
6. Guo, Mengbiao, Zhu, Jianxi, Hu, Zhijie, Songyang, Zhou, Xiong, Yuanyan. . Histone mRNA polyadenylation-mediated inflammation underlies various virus infections and cancers. In Journal of medical virology, 95, e28826. doi:10.1002/jmv.28826. https://pubmed.ncbi.nlm.nih.gov/37254821/
7. Coffin, Stephanie L, Durham, Mark A, Nitschke, Larissa, Orr, Harry T, Zoghbi, Huda Y. 2022. Disruption of the ATXN1-CIC complex reveals the role of additional nuclear ATXN1 interactors in spinocerebellar ataxia type 1. In Neuron, 111, 481-492.e8. doi:10.1016/j.neuron.2022.11.016. https://pubmed.ncbi.nlm.nih.gov/36577402/
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凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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