Snord59a-flox Mouse

Snord59a is a small nucleolar RNA with a C/D motif, belonging to the SNORD family. These noncoding RNAs are known to regulate ribosomal RNA assembly and function [2].

In human anaphylaxis, Snord59a was found to be significantly up-regulated in severe anaphylaxis compared to healthy controls, suggesting its potential involvement in the pathogenesis of anaphylaxis [1].

In the context of bisphenol A (BPA) exposure in human prostaspheres, Snord59a expression was reduced. BPA-induced gene silencing of Snord59a was associated with altered recruitments of histone marks (H3K9me3, H3K4me3, and H3K27me3) to its 5'-regulatory/exonic sequences, and its expression was also shown to be reduced in prostate cancer compared with adjacent normal tissue [2].

In summary, Snord59a is involved in ribosomal RNA-related functions. Its dysregulation in anaphylaxis and prostate cancer, as demonstrated through these studies, highlights its importance in understanding the pathogenesis of these conditions. The findings from these studies on Snord59a contribute to a better understanding of the molecular mechanisms underlying anaphylaxis and prostate cancer development [1,2].