Slc22a7-KO Mouse
一般名
Slc22a7-KO
製品ID
S-KO-00586
背景情報
C57BL/6JCya
系統ID
KOCMP-108114-Slc22a7-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Slc22a7-KO Mouse（カタログ番号S-KO-00586）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Slc22a7-KO
系統ID
KOCMP-108114-Slc22a7-B6J-VB
遺伝子名
製品ID
S-KO-00586
遺伝子別名
NLT, OAT2
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 17
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000087012
NCBIトランスクリプトID
NM_144856
ターゲット領域
Exon 1~4
有効領域の大きさ
~2.5 kb
遺伝子研究の概要
Slc22a7, also known as organic anion transporter 2 (OAT2), is a member of the solute carrier superfamily. It functions as a facilitative transporter for various substances such as cyclic nucleotides (like cGMP), nicotinic acid, creatinine, and uric acid [4,5,7,8]. It is involved in lipid metabolism through insulin, PI3K-Akt, MAPK, AMPK, mTOR, and PPAR signaling pathways [2]. It may also play a role in the renal handling of uric acid as a step in tubular secretion and could potentially regulate serum uric acid levels [6].
In a study on diabetic kidney disease (DKD) in mice, the mRNA expression level of Slc22a7 was declined in the kidney tissues of DKD mice compared with control mice, suggesting its involvement in lipid metabolism and the PPAR signaling pathway in DKD [1]. In Chinese Holstein cows, polymorphisms in the Slc22a7 gene were significantly associated with milk production traits, such as milk yield, fat yield, fat percentage, protein yield, or protein percentage [2]. Genetic variants in Slc22a7 were also associated with anthracycline-induced cardiotoxicity in children, and adding these variants to a prediction model improved its discriminative ability [3].
In conclusion, Slc22a7 is a key transporter with important functions in the transport of various substances and is involved in multiple biological processes and signaling pathways. Studies on mouse models for DKD, as well as research on cows and children, have revealed its potential roles in disease-related conditions, such as DKD and anthracycline-induced cardiotoxicity, and in traits like milk production in cows. These findings highlight the significance of Slc22a7 in different biological and medical contexts.
References:
1. Zhao, Jing, He, Kaiying, Du, Hongxuan, Zhou, Xiaochun, Wang, Jianqin. 2022. Bioinformatics prediction and experimental verification of key biomarkers for diabetic kidney disease based on transcriptome sequencing in mice. In PeerJ, 10, e13932. doi:10.7717/peerj.13932. https://pubmed.ncbi.nlm.nih.gov/36157062/
2. Jia, Ruike, Fu, Yihan, Xu, Lingna, Sun, Dongxiao, Han, Bo. 2021. Associations between polymorphisms of SLC22A7, NGFR, ARNTL and PPP2R2B genes and Milk production traits in Chinese Holstein. In BMC genomic data, 22, 47. doi:10.1186/s12863-021-01002-0. https://pubmed.ncbi.nlm.nih.gov/34732138/
3. Visscher, Henk, Rassekh, S Rod, Sandor, George S, Hayden, Michael R, Ross, Colin J. 2015. Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children. In Pharmacogenomics, 16, 1065-76. doi:10.2217/pgs.15.61. https://pubmed.ncbi.nlm.nih.gov/26230641/
4. Sager, Georg, Smaglyukova, Natalia, Fuskevaag, Ole-Martin. 2018. The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes. In Journal of cellular physiology, 233, 5972-5980. doi:10.1002/jcp.26409. https://pubmed.ncbi.nlm.nih.gov/29244191/
5. Mathialagan, Sumathy, Bi, Yi-An, Costales, Chester, Rodrigues, A David, Varma, Manthena V S. 2020. Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7). In Biochemical pharmacology, 174, 113829. doi:10.1016/j.bcp.2020.113829. https://pubmed.ncbi.nlm.nih.gov/32001236/
6. Sato, Masanobu, Mamada, Hideaki, Anzai, Naohiko, Nakanishi, Takeo, Tamai, Ikumi. . Renal secretion of uric acid by organic anion transporter 2 (OAT2/SLC22A7) in human. In Biological & pharmaceutical bulletin, 33, 498-503. doi:. https://pubmed.ncbi.nlm.nih.gov/20190416/
7. Shen, Hong, Liu, Tongtong, Morse, Bridget L, Marathe, Punit, Lai, Yurong. 2015. Characterization of Organic Anion Transporter 2 (SLC22A7): A Highly Efficient Transporter for Creatinine and Species-Dependent Renal Tubular Expression. In Drug metabolism and disposition: the biological fate of chemicals, 43, 984-93. doi:10.1124/dmd.114.062364. https://pubmed.ncbi.nlm.nih.gov/25904762/
8. Cropp, Cheryl D, Komori, Takafumi, Shima, James E, More, Swati S, Giacomini, Kathleen M. 2008. Organic anion transporter 2 (SLC22A7) is a facilitative transporter of cGMP. In Molecular pharmacology, 73, 1151-8. doi:10.1124/mol.107.043117. https://pubmed.ncbi.nlm.nih.gov/18216183/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。