Mta1-KO Mouse

MTA1, or metastasis-associated antigen-1, is a transcriptional coregulator and a member of the MTA family. It is an integral part of the nuclear remodeling and deacetylation complex (NuRD), regulating gene expression by altering epigenetic changes like acetylation and methylation on target gene chromatin [3]. MTA1 is involved in cell signaling, chromosomal remodeling, and transcriptional activities, which are crucial for epithelial cell progression, invasion, and growth [1].

MTA1 has been found to play significant roles in multiple cancers. In prostate cancer, its expression is linked to bone metastases and is considered a potential target for prevention and treatment [1]. In breast cancer, RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote cancer progression and bone metastasis [2]. In non-small cell lung cancer, MTA1 promotes invasion and metastasis by inhibiting the expression of TJP1 protein and weakening cell-cell tight junctions [4]. In endothelial cells, MTA1 is essential for angiogenesis, and its knockout significantly suppresses tube formation [5].

In conclusion, MTA1 is a key regulator in multiple biological processes related to cancer. Its roles in cancer progression, metastasis, and angiogenesis, as revealed through functional studies including gene knockout models in different cancer types, highlight its potential as a therapeutic target for various cancers such as prostate, breast, non-small cell lung cancer, etc. [1,2,4,5].

References:

1. Ma, Jialu, Li, Chunxiao, Qian, Haili, Zhang, Yong. . MTA1: A Vital Modulator in Prostate Cancer. In Current protein & peptide science, 23, 456-464. doi:10.2174/1389203723666220705152713. https://pubmed.ncbi.nlm.nih.gov/35792131/

2. Yin, Xin, Teng, Xu, Ma, Tianyu, Huang, Wei, Wang, Yan. 2022. RUNX2 recruits the NuRD(MTA1)/CRL4B complex to promote breast cancer progression and bone metastasis. In Cell death and differentiation, 29, 2203-2217. doi:10.1038/s41418-022-01010-2. https://pubmed.ncbi.nlm.nih.gov/35534547/

3. Malisetty, Vijaya Lakshmi, Penugurti, Vasudevarao, Panta, Prashanth, Chitta, Suresh Kumar, Manavathi, Bramanandam. 2017. MTA1 expression in human cancers - Clinical and pharmacological significance. In Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 95, 956-964. doi:10.1016/j.biopha.2017.09.025. https://pubmed.ncbi.nlm.nih.gov/28915537/

4. Wang, Wei, Ma, Mingsheng, Li, Li, Wang, Biying, Ye, Lianhua. 2022. MTA1-TJP1 interaction and its involvement in non-small cell lung cancer metastasis. In Translational oncology, 25, 101500. doi:10.1016/j.tranon.2022.101500. https://pubmed.ncbi.nlm.nih.gov/35944414/

5. Ishikawa, Mizuho, Osaki, Mitsuhiko, Uno, Narumi, Kugoh, Hiroyuki, Okada, Futoshi. 2021. MTA1, a metastasis‑associated protein, in endothelial cells is an essential molecule for angiogenesis. In Molecular medicine reports, 25, . doi:10.3892/mmr.2021.12527. https://pubmed.ncbi.nlm.nih.gov/34779499/