Ifi44l-KO Mouse
一般名
Ifi44l-KO
製品ID
S-KO-02404
背景情報
C57BL/6NCya
系統ID
KOCMP-15061-Ifi44l-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Ifi44l-KO Mouse（カタログ番号S-KO-02404）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Ifi44l-KO
系統ID
KOCMP-15061-Ifi44l-B6N-VA
遺伝子名
製品ID
S-KO-02404
遺伝子別名
H28, H-28, H28-1, NS1178
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conventional knockout
染色体
Chr 3
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000046739
NCBIトランスクリプトID
NM_031367
ターゲット領域
Exon 1~3
有効領域の大きさ
~4.2 kb
遺伝子研究の概要
Interferon-induced protein 44-like (IFI44L) is an immune-related gene and a member of interferon-stimulated genes (ISGs). It participates in network transduction, epigenetic modifications, apoptosis, cell-matrix formation, and other pathways, playing a crucial role in tumors, autoimmune diseases, and viral infections [1].
IFI44L expression is induced by IFN and HIV-1 infection, and is regulated by IRF-1 through binding to one of its IFN-stimulated response elements (ISREs) [2]. In lung carcinogenesis, IFI44L acts as a tumor suppressor, promoting apoptosis via the JAK/STAT1 pathway [3]. In tuberculosis, it serves as an antimicrobial target and positive modulator in human macrophages, restricting Mycobacterium tuberculosis intracellular survival [4]. In proliferative diabetic retinopathy, IFI44L may be a biomarker, potentially affecting disease progression by regulating metabolism-related and inflammatory pathways [5]. In systemic lupus erythematosus, it may play a role through abnormal regulation of the type I interferon signalling pathway, and its overexpression in monocytes enhances the maturation and functions of monocyte-derived dendritic cells [6,9]. Variant forms of the IFI44L gene are protective against early-childhood respiratory tract infections or acute otitis media, attenuating IFN pathway activation by respiratory viruses [8]. In head and neck squamous cell carcinoma, ACSL4 upregulates IFI44L expression, promoting cell proliferation and invasiveness [7].
In summary, IFI44L is significantly involved in multiple biological processes and disease conditions, such as cancer, autoimmune diseases, and infections. Its role in these areas has been revealed through various functional studies, which may provide new perspectives for understanding disease mechanisms and developing potential therapeutic strategies.
References:
1. Du, Juan, Luo, Hui, Ye, Shuang, Zheng, Zhen, Liu, Kaitai. 2024. Unraveling IFI44L's biofunction in human disease. In Frontiers in oncology, 14, 1436576. doi:10.3389/fonc.2024.1436576. https://pubmed.ncbi.nlm.nih.gov/39737399/
2. Li, Yutong, Zhang, Junshi, Wang, Chenchen, Li, Yue, Tan, Juan. 2020. IFI44L expression is regulated by IRF-1 and HIV-1. In FEBS open bio, 11, 105-113. doi:10.1002/2211-5463.13030. https://pubmed.ncbi.nlm.nih.gov/33159419/
3. Zeng, Yong, Chen, Hong-Qiang, Zhang, Zhe, Zhou, Zi-Yuan, Liu, Wen-Bin. 2022. IFI44L as a novel epigenetic silencing tumor suppressor promotes apoptosis through JAK/STAT1 pathway during lung carcinogenesis. In Environmental pollution (Barking, Essex : 1987), 319, 120943. doi:10.1016/j.envpol.2022.120943. https://pubmed.ncbi.nlm.nih.gov/36584854/
4. Jiang, Haiqin, Tsang, Lemuel, Wang, Hongsheng, Liu, Changhong. 2021. IFI44L as a Forward Regulator Enhancing Host Antituberculosis Responses. In Journal of immunology research, 2021, 5599408. doi:10.1155/2021/5599408. https://pubmed.ncbi.nlm.nih.gov/34722780/
5. Shang, Mingxin, Zhang, Yao, Zhang, Tongtong. . IFI44L and C1QTNF5 as promising biomarkers of proliferative diabetic retinopathy. In Medicine, 101, e31961. doi:10.1097/MD.0000000000031961. https://pubmed.ncbi.nlm.nih.gov/36451477/
6. Wang, Yuan, Jia, Wei, Ma, Qian, Huo, Zhenghao, Dang, Jie. 2022. Identification of IFI44L as a new candidate molecular marker for systemic lupus erythematosus. In Clinical and experimental rheumatology, 41, 48-59. doi:10.55563/clinexprheumatol/q3aa6s. https://pubmed.ncbi.nlm.nih.gov/35349411/
7. Rupa, Darius, Chuang, Hao-Wen, Hu, Chung-En, Lee, Herng-Sheng, Yuan, Ta-Chun. 2024. ACSL4 upregulates IFI44 and IFI44L expression and promotes the proliferation and invasiveness of head and neck squamous cell carcinoma cells. In Cancer science, 115, 3026-3040. doi:10.1111/cas.16236. https://pubmed.ncbi.nlm.nih.gov/38989827/
8. Lempainen, Johanna, Korhonen, Laura S, Kantojärvi, Katri, Paunio, Tiina, Peltola, Ville. . Associations Between IFI44L Gene Variants and Rates of Respiratory Tract Infections During Early Childhood. In The Journal of infectious diseases, 223, 157-165. doi:10.1093/infdis/jiaa341. https://pubmed.ncbi.nlm.nih.gov/32561935/
9. Luo, Shuaihantian, Wu, Ruifang, Li, Qianwen, Zhang, Guiying. 2022. Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus. In Journal of immunology research, 2022, 4053038. doi:10.1155/2022/4053038. https://pubmed.ncbi.nlm.nih.gov/35592687/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。