Hnrnpc-KO Mouse
一般名
Hnrnpc-KO
製品ID
S-KO-02476
背景情報
C57BL/6JCya
系統ID
KOCMP-15381-Hnrnpc-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Hnrnpc-KO Mouse（カタログ番号S-KO-02476）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Hnrnpc-KO
系統ID
KOCMP-15381-Hnrnpc-B6J-VA
遺伝子名
製品ID
S-KO-02476
遺伝子別名
Hnrpc, Hnrpc1, Hnrpc2, hnRNPC1, hnRNPC2, hnrnp-C, D14Wsu171e
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 14
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000111610
NCBIトランスクリプトID
NM_016884.4
ターゲット領域
Exon 4~5
有効領域の大きさ
~1.7 kb
遺伝子研究の概要
Hnrnpc, also known as heterogeneous nuclear ribonucleoprotein C (C1/C2), is an essential and ubiquitously abundant protein involved in mRNA processing. It participates in nucleic acid metabolism and has been linked to multiple biological processes [1,2]. Dysregulation of Hnrnpc has been associated with various diseases, including cancer and neurodevelopmental disorders [1,2].
In cancer, Hnrnpc plays significant roles. In hepatocellular carcinoma (HCC), its downregulation inhibits IL-6/STAT3-mediated metastasis by decreasing HIF1A expression, and patients with positive Hnrnpc expression have decreased overall survival and increased recurrence rate [1]. In clear cell renal cell carcinoma, circPPAP2B promotes metastasis via Hnrnpc-dependent alternative splicing [3]. In cervical cancer, Hnrnpc mediates lymphatic metastasis through m6A-dependent alternative splicing of FOXM1 [4]. In papillary thyroid carcinoma, Hnrnpc modulates PKM alternative splicing via m6A methylation to promote aerobic glycolysis and drive malignant progression [5]. In breast cancer, Hnrnpc promotes collagen fiber alignment and immune evasion via activation of the VIRMA-mediated TFAP2A/DDR1 axis [6]. In autoimmune thyroid disease, targeting Hnrnpc suppresses thyroid follicular epithelial cell apoptosis and necroptosis through m6A-modified ATF4 [7]. In addition, Hnrnpc haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder [2].
In conclusion, Hnrnpc is crucial in mRNA processing and nucleic acid metabolism. Its dysregulation is associated with various cancers and a neurodevelopmental disorder. Studies, especially those using loss-of-function models in different disease contexts, have revealed its diverse roles in promoting tumor metastasis, regulating cell metabolism, and affecting alternative splicing related to disease-associated genes. This understanding provides potential targets for diagnosis, prognosis, and treatment in these diseases.
References:
1. Liu, Danfei, Luo, Xiangyuan, Xie, Meng, Huang, Wenjie, Xia, Limin. 2022. HNRNPC downregulation inhibits IL-6/STAT3-mediated HCC metastasis by decreasing HIF1A expression. In Cancer science, 113, 3347-3361. doi:10.1111/cas.15494. https://pubmed.ncbi.nlm.nih.gov/35848884/
2. Niggl, Eva, Bouman, Arjan, Briere, Lauren C, Elgersma, Ype, van Esbroeck, Annelot C M. . HNRNPC haploinsufficiency affects alternative splicing of intellectual disability-associated genes and causes a neurodevelopmental disorder. In American journal of human genetics, 110, 1414-1435. doi:10.1016/j.ajhg.2023.07.005. https://pubmed.ncbi.nlm.nih.gov/37541189/
3. Zheng, Zaosong, Zeng, Xiangbo, Zhu, Yuanchao, Li, Fei, Tan, Wanlong. 2024. CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis. In Molecular cancer, 23, 4. doi:10.1186/s12943-023-01912-w. https://pubmed.ncbi.nlm.nih.gov/38184608/
4. Liu, Yun-Yun, Xia, Meng, Chen, Zhi-Bo, Lu, Huai-Wu, Yao, Shu-Zhong. 2024. HNRNPC mediates lymphatic metastasis of cervical cancer through m6A-dependent alternative splicing of FOXM1. In Cell death & disease, 15, 732. doi:10.1038/s41419-024-07108-4. https://pubmed.ncbi.nlm.nih.gov/39375330/
5. Rong, Shikuo, Dai, Bao, Yang, Chunrong, Chen, Jian, Wu, Zeyu. 2024. HNRNPC modulates PKM alternative splicing via m6A methylation, upregulating PKM2 expression to promote aerobic glycolysis in papillary thyroid carcinoma and drive malignant progression. In Journal of translational medicine, 22, 914. doi:10.1186/s12967-024-05668-9. https://pubmed.ncbi.nlm.nih.gov/39380010/
6. Lian, Bin, Yan, Shuxun, Li, Jiayi, Bai, Zhengyang, Li, Jinping. 2023. HNRNPC promotes collagen fiber alignment and immune evasion in breast cancer via activation of the VIRMA-mediated TFAP2A/DDR1 axis. In Molecular medicine (Cambridge, Mass.), 29, 103. doi:10.1186/s10020-023-00696-5. https://pubmed.ncbi.nlm.nih.gov/37528369/
7. Mo, Ke, Chu, Yongli, Liu, Yang, Song, Xicheng, Zhou, Jin. 2023. Targeting hnRNPC suppresses thyroid follicular epithelial cell apoptosis and necroptosis through m6A-modified ATF4 in autoimmune thyroid disease. In Pharmacological research, 196, 106933. doi:10.1016/j.phrs.2023.106933. https://pubmed.ncbi.nlm.nih.gov/37729957/
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