Kif11-KO Mouse
一般名
Kif11-KO
製品ID
S-KO-02779
背景情報
C57BL/6JCya
系統ID
KOCMP-16551-Kif11-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Kif11-KO Mouse（カタログ番号S-KO-02779）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Kif11-KO
系統ID
KOCMP-16551-Kif11-B6J-VA
遺伝子名
製品ID
S-KO-02779
遺伝子別名
Eg5, Kif8, Kifl1, Knsl1
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 19
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000012587
NCBIトランスクリプトID
NM_010615
ターゲット領域
Exon 2~4
有効領域の大きさ
~2.7 kb
遺伝子研究の概要
KIF11, a member of the kinesin family, plays a vital role in the formation and maintenance of the mitotic spindle, thus being crucial for cell division. It is also involved in various cellular processes, such as those related to the cell cycle [3].
KIF11 depletion in photoreceptor cells causes malformations of the ciliary axoneme and membranous discs, leading to photoreceptor degeneration and drusen-like deposits in the retina. This indicates its importance in maintaining photoreceptor cilium integrity and retinal homeostasis [1]. In hepatocellular carcinoma, KIF11-dependent repression of CDKN2A by lncRNA NEAT1 is associated with reduced cellular senescence and promoted tumor progression. Knockdown of KIF11 causes senescence in cultured hepatoma cells [2]. In multiple cancers like endometrial, thyroid, NSCLC, pancreatic ductal adenocarcinoma, adrenocortical carcinoma, childhood acute lymphoblastic leukemia, and Wilms tumor, high KIF11 expression is linked to tumorigenesis, progression, and poor prognosis. Loss-of-function experiments, such as knockdown of KIF11, inhibit cancer cell proliferation, migration, invasion, and induce apoptosis or cell cycle arrest [4,5,6,7,8,9,10].
In conclusion, KIF11 is essential for mitosis and the cell cycle. Model-based research, especially loss-of-function experiments, has revealed its significant roles in retinal homeostasis and cancer development. These findings suggest KIF11 could be a potential therapeutic target for diseases like cancer and retinal disorders.
References:
1. Ran, Jie, Guo, Guizhi, Zhang, Sai, Zhou, Jun, Liu, Min. 2024. KIF11 UFMylation Maintains Photoreceptor Cilium Integrity and Retinal Homeostasis. In Advanced science (Weinheim, Baden-Wurttemberg, Germany), 11, e2400569. doi:10.1002/advs.202400569. https://pubmed.ncbi.nlm.nih.gov/38666385/
2. Chen, Danlei, Wang, Jinghao, Li, Yang, Zhang, Pengfei, Liu, Lianxin. . LncRNA NEAT1 suppresses cellular senescence in hepatocellular carcinoma via KIF11-dependent repression of CDKN2A. In Clinical and translational medicine, 13, e1418. doi:10.1002/ctm2.1418. https://pubmed.ncbi.nlm.nih.gov/37752791/
3. Gao, Wanting, Lu, Junjie, Yang, Zitao, Cao, Yufei, Xie, Lei. 2024. Mitotic Functions and Characters of KIF11 in Cancers. In Biomolecules, 14, . doi:10.3390/biom14040386. https://pubmed.ncbi.nlm.nih.gov/38672404/
4. Wang, Biying, Bao, Lunmin, Li, Xiaoduo, Yuan, Rui, Jiang, Hongmei. 2025. Identification and validation of the important role of KIF11 in the development and progression of endometrial cancer. In Journal of translational medicine, 23, 48. doi:10.1186/s12967-025-06081-6. https://pubmed.ncbi.nlm.nih.gov/39806429/
5. Han, Yue, Chen, Jing, Wei, Dianjun, Wang, Baoxi. 2022. KIF11 Is a Promising Therapeutic Target for Thyroid Cancer Treatment. In Computational and mathematical methods in medicine, 2022, 6426800. doi:10.1155/2022/6426800. https://pubmed.ncbi.nlm.nih.gov/36017147/
6. Liu, Junhui, Tian, Yubin, Yi, Lei, Lou, Ming, Yuan, Kai. 2021. High KIF11 expression is associated with poor outcome of NSCLC. In Tumori, 108, 40-46. doi:10.1177/0300891620988342. https://pubmed.ncbi.nlm.nih.gov/33554761/
7. Gu, Xiang, Zhu, Qunshan, Tian, Guangyu, Chen, Xiaojun, Qin, Songbing. 2022. KIF11 manipulates SREBP2-dependent mevalonate cross talk to promote tumor progression in pancreatic ductal adenocarcinoma. In Cancer medicine, 11, 3282-3295. doi:10.1002/cam4.4683. https://pubmed.ncbi.nlm.nih.gov/35619540/
8. Zhou, Yan, Chen, Xiang, Li, Bingsheng, Li, Yang, Zhang, Bo. 2023. KIF11 is a potential prognostic biomarker and therapeutic target for adrenocortical carcinoma. In Translational andrology and urology, 12, 594-611. doi:10.21037/tau-22-706. https://pubmed.ncbi.nlm.nih.gov/37181234/
9. Zhu, Liwen, Chen, Chuqin, Kang, Meiyun, Xue, Yao, Fang, Yongjun. 2023. KIF11 serves as a cell cycle mediator in childhood acute lymphoblastic leukemia. In Journal of cancer research and clinical oncology, 149, 15609-15622. doi:10.1007/s00432-023-05240-w. https://pubmed.ncbi.nlm.nih.gov/37656243/
10. Luo, Yishu, Liu, Wei, Zhu, Yinmei, Liu, Xiaoqin, Zhao, Jun. 2021. KIF11 as a potential cancer prognostic marker promotes tumorigenesis in children with Wilms tumor. In Pediatric hematology and oncology, 39, 145-157. doi:10.1080/08880018.2021.1953655. https://pubmed.ncbi.nlm.nih.gov/34378481/
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凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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