9330159F19Rik-KO Mouse

9330159F19Rik, with currently no widely-known common aliases, has been found to be involved in pathways related to lipid, amino acid metabolism, insulin resistance, and extracellular matrix (ECM)-related processes based on the analysis of differentially expressed mRNAs in adipose tissues [1]. It is a key gene in the ceRNA regulatory network, suggesting its importance in regulating gene expression at the post-transcriptional level in adipose-related biological functions.

In a study comparing the adipose tissues of the sham group and the duodenal-jejunal bypass (DJB) group, 9330159F19Rik was identified as one of the 31 hub differentially expressed mRNAs in the ceRNA regulatory network of DElncRNAs and DEcircRNAs. This implies that DJB may impact adipose tissue remodeling of ECM and energy metabolism through the ceRNA network where 9330159F19Rik is involved [1].

In conclusion, 9330159F19Rik is crucial in the ceRNA regulatory network associated with adipose tissue's ECM remodeling and energy metabolism. Research on 9330159F19Rik, especially through in-vivo studies like the comparison in the DJB-related model, helps understand the molecular mechanisms underlying adipose-related metabolic processes, which may potentially contribute to the study of obesity-related diseases and metabolic disorders [1].

References:

1. Zhao, Qingnan, Cheng, Jiaxin, Gao, Aimei, Zhu, Han, Liang, Yongjun. 2023. Duodenal-Jejunal bypass improves metabolism and re-models extra cellular matrix through modulating ceRNA network. In Genomics, 115, 110744. doi:10.1016/j.ygeno.2023.110744. https://pubmed.ncbi.nlm.nih.gov/37972907/