Tac1-KO Mouse
一般名
Tac1-KO
製品ID
S-KO-04905
背景情報
C57BL/6JCya
系統ID
KOCMP-21333-Tac1-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Tac1-KO Mouse（カタログ番号S-KO-04905）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Tac1-KO
系統ID
KOCMP-21333-Tac1-B6J-VA
遺伝子名
製品ID
S-KO-04905
遺伝子別名
SP, NK1, NK-1, Nkna, PPTA, PPT-A, 4930528L02Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 6
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000185187
NCBIトランスクリプトID
NM_009311
ターゲット領域
Exon 2~7
有効領域の大きさ
~7.4 kb
遺伝子研究の概要
Tac1, also known as tachykinin 1 or transcriptional activator candidate 1, has diverse functions. In Candida albicans, it encodes a transcription factor regulating drug resistance genes like efflux pump genes (CDR1, CDR2, MDR1) and ERG11, with mutations conferring azole resistance [1,6]. In mammals, it is involved in neural circuits related to various behaviors. Tac1 -expressing neurons in different brain regions are associated with behaviors such as the itch-scratching cycle, toxin-induced defensive responses, male sexual behavior, stress-induced anhedonia, social interactions, and avoidance of aversive stimuli, as well as odor-driven innate fear and anxiety [2,3,4,5,7,8,9].
In mouse models, ablation or suppression of Tac1-expressing neurons in the lateral and ventrolateral periaqueductal gray (l/vlPAG) decreased itch-induced scratching behavior, indicating their role in promoting the itch-scratching cycle [2]. In the gut-to-brain axis study, manipulating the circuit involving Tac1+ neurons in the dorsal vagal complex (DVC) interfered with toxin-induced defensive responses [3]. In the study of male sexual behavior, epistasis studies on a neural circuit including BNSTprTac1 neurons demonstrated their upstream role in initiating mating [4]. In the context of anhedonia-like behavior, selective inhibition and activation of Tac1-expressing neurons in the nucleus accumbens lateral shell bidirectionally modulated stress susceptibility [5].
In conclusion, Tac1 is crucial in multiple biological processes and disease-related behaviors. Mouse models with manipulated Tac1-expressing neurons have revealed its roles in behaviors related to itch, toxin response, sexual behavior, anhedonia, social interactions, aversion, and fear. Understanding Tac1 may provide insights into the mechanisms of these behaviors and potential therapeutic targets for related disorders.
References:
1. Mahdizade, Amir Hossein, Hoseinnejad, Akbar, Ghazanfari, Mona, Haghani, Iman, Romeo, Orazio. 2024. The TAC1 Gene in Candida albicans: Structure, Function, and Role in Azole Resistance: A Mini-Review. In Microbial drug resistance (Larchmont, N.Y.), 30, 288-296. doi:10.1089/mdr.2023.0334. https://pubmed.ncbi.nlm.nih.gov/38770776/
2. Gao, Zheng-Run, Chen, Wen-Zhen, Liu, Ming-Zhe, Xu, Xiao-Hong, Sun, Yan-Gang. 2018. Tac1-Expressing Neurons in the Periaqueductal Gray Facilitate the Itch-Scratching Cycle via Descending Regulation. In Neuron, 101, 45-59.e9. doi:10.1016/j.neuron.2018.11.010. https://pubmed.ncbi.nlm.nih.gov/30554781/
3. Xie, Zhiyong, Zhang, Xianying, Zhao, Miao, Shang, Congping, Cao, Peng. 2022. The gut-to-brain axis for toxin-induced defensive responses. In Cell, 185, 4298-4316.e21. doi:10.1016/j.cell.2022.10.001. https://pubmed.ncbi.nlm.nih.gov/36323317/
4. Bayless, Daniel W, Davis, Chung-Ha O, Yang, Renzhi, Luo, Liqun, Shah, Nirao M. 2023. A neural circuit for male sexual behavior and reward. In Cell, 186, 3862-3881.e28. doi:10.1016/j.cell.2023.07.021. https://pubmed.ncbi.nlm.nih.gov/37572660/
5. He, Zi-Xuan, Yin, Yue-Yue, Xi, Ke, Yu, Hua-Li, Zhu, Xiao-Juan. . Nucleus Accumbens Tac1-Expressing Neurons Mediate Stress-Induced Anhedonia-like Behavior in Mice. In Cell reports, 33, 108343. doi:10.1016/j.celrep.2020.108343. https://pubmed.ncbi.nlm.nih.gov/33147466/
6. Czajka, Karolina M, Venkataraman, Krishnan, Brabant-Kirwan, Danielle, Saunders, Deborah P, Tharmalingam, Sujeenthar. 2023. Molecular Mechanisms Associated with Antifungal Resistance in Pathogenic Candida Species. In Cells, 12, . doi:10.3390/cells12222655. https://pubmed.ncbi.nlm.nih.gov/37998390/
7. Yu, Hang, Miao, Wanying, Ji, En, Xu, Fuqiang, Yu, Xiang. 2022. Social touch-like tactile stimulation activates a tachykinin 1-oxytocin pathway to promote social interactions. In Neuron, 110, 1051-1067.e7. doi:10.1016/j.neuron.2021.12.022. https://pubmed.ncbi.nlm.nih.gov/35045339/
8. He, Zi-Xuan, Xi, Ke, Liu, Kai-Jie, Xing, Zhen-Kai, Zhu, Xiao-Juan. 2023. A Nucleus Accumbens Tac1 Neural Circuit Regulates Avoidance Responses to Aversive Stimuli. In International journal of molecular sciences, 24, . doi:10.3390/ijms24054346. https://pubmed.ncbi.nlm.nih.gov/36901777/
9. Wang, Hao, Wang, Qin, Cui, Liuzhe, Cao, Peng, Li, Xiao-Ming. 2024. A molecularly defined amygdala-independent tetra-synaptic forebrain-to-hindbrain pathway for odor-driven innate fear and anxiety. In Nature neuroscience, 27, 514-526. doi:10.1038/s41593-023-01562-7. https://pubmed.ncbi.nlm.nih.gov/38347199/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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