Oosp2-KO Mouse

Oosp2 is a member of the Oosp family genes. While its specific aliases are not provided in the given references, it has been linked to the female reproductive system. In human oocyte maturation, it has been found to play a functional role. Oosp2 inducing factor can trigger specific signaling pathways, such as those involving small GTPases, through translational regulation during human oocyte maturation [1].

CRISPR/Cas9-mediated knockout of three Oosp family genes (including Oosp2) in mice led to decreased prolificacy but not infertility. This indicates that Oosp2 may be dispensable for female fertility in mice [2].

In summary, Oosp2 appears to have a role in human oocyte maturation, potentially through translational regulation of signaling pathways. In mouse models, gene knockout of Oosp2 as part of a triple-knockout of Oosp family genes suggests its dispensability for female fertility. These findings contribute to our understanding of the molecular mechanisms underlying female reproduction and may have implications for fertility-related research.

References:

1. Hu, Wenqi, Zeng, Haitao, Shi, Yanan, Liang, Xiaoyan, Kee, Kehkooi. 2022. Single-cell transcriptome and translatome dual-omics reveals potential mechanisms of human oocyte maturation. In Nature communications, 13, 5114. doi:10.1038/s41467-022-32791-2. https://pubmed.ncbi.nlm.nih.gov/36042231/

2. Abbasi, Ferheen, Kodani, Mayo, Emori, Chihiro, Fujihara, Yoshitaka, Ikawa, Masahito. 2020. CRISPR/Cas9-Mediated Genome Editing Reveals Oosp Family Genes are Dispensable for Female Fertility in Mice. In Cells, 9, . doi:10.3390/cells9040821. https://pubmed.ncbi.nlm.nih.gov/32231122/