BC028528-KO Mouse

BC028528 is an alias for C1orf54. C1orf54 is a protein-encoding gene located on chromosome 1. It functions in promoting tubular epithelial cell (TEC) proliferation through the PI3K/AKT signalling pathway. Its expression is relatively high in the kidney compared to other tissues like heart, liver, spleen, lung and skeletal muscle, and in the kidney, it is expressed in TECs but not in glomeruli. Genetic models such as knockout mice can be used to study its function [1].

In C1orf54-knockout mice relative to wild-type mice, after kidney ischaemia-reperfusion injury (IRI), there is impaired TEC proliferation and delayed recovery. This leads to deteriorated renal function and increased mortality. In contrast, adenovirus-mediated C1orf54 overexpression promotes TEC proliferation, ameliorates kidney pathology, accelerates renal repair and improves renal function [1].

In conclusion, C1orf54, also known as BC028528, plays a crucial role in promoting TEC proliferation through the PI3K/AKT pathway, which is essential for renal repair after IRI. The use of C1orf54-knockout mouse models has revealed its significance in kidney IRI, suggesting it as a potential therapeutic target for this condition [1].

References:

1. Xie, Hongyang, Wang, Yaqiong, Zhang, Hang, Zhang, Ruiyan, Yan, Xiaoxiang. 2018. Tubular epithelial C1orf54 mediates protection and recovery from acute kidney injury. In Journal of cellular and molecular medicine, 22, 4985-4996. doi:10.1111/jcmm.13765. https://pubmed.ncbi.nlm.nih.gov/29999589/