Abhd18-KO Mouse

Abhd18, without common aliases mentioned, is potentially involved in muscle growth and development. Through pathway analysis, relevant pathways like ether lipid metabolism, cortisol synthesis and secretion, and calcium signaling pathways, which Abhd18 might be a part of, are known to play pivotal roles in muscle growth and development [1].

In a study analyzing muscle transcriptomes of bovine, porcine, and sheep using interpretable machine learning models, Abhd18 was identified as a specific candidate gene for cattle among the key genes (SHAP genes) potentially influencing muscle growth and development across the three species [1].

In conclusion, Abhd18 appears to be a gene of importance in muscle growth and development, especially in cattle. Its identification as a candidate gene in this cross-species muscle transcriptome study contributes to understanding the genetic mechanisms underlying muscle development, which may have implications for the meat industry in terms of enhancing muscle quality and growth efficiency [1].

References:

1. Guo, Yaqiang, Li, Shuai, Na, Rigela, Gu, Mingjuan, Zhang, Wenguang. 2024. Comparative Transcriptome Analysis of Bovine, Porcine, and Sheep Muscle Using Interpretable Machine Learning Models. In Animals : an open access journal from MDPI, 14, . doi:10.3390/ani14202947. https://pubmed.ncbi.nlm.nih.gov/39457877/