Rmnd5b-KO Mouse

Rmnd5b is a member of the CTLH (carboxy-terminal to LisH) complex, which has E3-ligase enzymatic activity. The CTLH complex is involved in fundamental biological processes like proliferation, survival, programmed cell death, cell adhesion, and migration, and interacts with key signaling pathways such as PI3-kinase, WNT, TGFβ, and NFκB, all of which are crucial for cancer cell plasticity [1].

In esophageal squamous cell carcinoma (ESCC), bioinformatic analysis identified RMND5B as a prognosis-related gene, and a risk-score model based on immune cell-related genes (including RMND5B) was constructed, providing new ideas for ESCC treatment and prognosis studies [2]. In pancreatic adenocarcinoma (PAAD), a ZNF family genes-related risk score model based on 10 genes including RMND5B was established, and the risk score was a significant independent prognostic factor for PAAD patients [3]. Also, in acute myeloid leukemia (AML), a prognostic model containing RMND5B was constructed, which accurately predicted AML prognosis [4].

In conclusion, RMND5B, as part of the CTLH complex, is involved in multiple biological processes related to cancer cell plasticity. Its identification in prognosis-related gene models for ESCC, PAAD, and AML suggests its importance in understanding the prognosis and potentially developing treatment strategies for these cancers.

References:

1. Huffman, Nickelas, Palmieri, Dario, Coppola, Vincenzo. 2019. The CTLH Complex in Cancer Cell Plasticity. In Journal of oncology, 2019, 4216750. doi:10.1155/2019/4216750. https://pubmed.ncbi.nlm.nih.gov/31885576/

2. Wang, Xian, Peng, Wei, Zhao, Yali, Huang, Shan, Wang, Hua. 2024. Immune cell related signature predicts prognosis in esophageal squamous cell carcinoma based on single-cell and bulk-RNA sequencing. In Frontiers in oncology, 14, 1370801. doi:10.3389/fonc.2024.1370801. https://pubmed.ncbi.nlm.nih.gov/38903709/

3. Zhu, Lei, Tu, Dong, Li, Ruixue, Li, Tiehan, Zhu, Hong. 2023. The diagnostic significance of the ZNF gene family in pancreatic cancer: a bioinformatics and experimental study. In Frontiers in genetics, 14, 1089023. doi:10.3389/fgene.2023.1089023. https://pubmed.ncbi.nlm.nih.gov/37396042/

4. Ling, Chun, Cao, Nengneng, Wang, Huiping, Zhang, Qiguo, Zhai, Zhimin. 2025. Systematic Analysis of E3 Ligase-Related Genes Identified UBE2L3 as a Prognostic Biomarker Associated With Drug Resistance in Acute Myeloid Leukemia. In International journal of general medicine, 18, 459-472. doi:10.2147/IJGM.S502644. https://pubmed.ncbi.nlm.nih.gov/39895829/