Oip5os1-KO Mouse

Oip5os1, also known as 1700020I14Rik, OIP5-AS1, and Cyrano, is a long non-coding RNA (lncRNA) [4]. It is broadly expressed across multiple tissues, with significant enrichment in the nervous system, skeletal muscle, and striated muscles [4]. It has regulatory functions in normal cellular processes such as cell proliferation and survival [4].

In a study of male mice, deletion of Oip5os1 in the setting of streptozotocin-induced diabetes led to left atrial dysfunction and myopathy, associated with anesthesia intolerance and premature death in most KO mice. There was a reduction in the metabolic regulator ERRalpha and a trend for a reduction in Serca2a in the atria of KO mice compared to WT mice, highlighting its role in atrial function in diabetes [1]. In CUMS-induced mice, geniposide regulated the Oip5os1/miR-25-3p/Gata2 network to alleviate depression-like behaviors [2]. Also, PFOS exposure downregulated Oip5os1 in pregnant mice, impairing trophoblast proliferation and migration via the Oip5os1/miR-155/Rnd3 axis, contributing to pre-eclampsia development [3].

In conclusion, Oip5os1 is a context-specific regulator involved in normal cellular processes like cell proliferation and survival. Gene knockout mouse models have revealed its importance in atrial function in diabetes, depression-like behaviors, and pre-eclampsia development, helping to understand the mechanisms of these disease conditions [1,2,3].

References:

1. Zhuang, Aowen, Tan, Yanie, Liu, Yingying, Calkin, Anna C, Drew, Brian G. . Deletion of the muscle enriched lncRNA Oip5os1 induces atrial dysfunction in male mice with diabetes. In Physiological reports, 11, e15869. doi:10.14814/phy2.15869. https://pubmed.ncbi.nlm.nih.gov/38054572/

2. Zhao, Yu, Zhang, Qian, Yan, Yuzhu, Mei, Cheng, Zou, Tianyu. 2022. Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks. In Phytotherapy research : PTR, 37, 1850-1863. doi:10.1002/ptr.7702. https://pubmed.ncbi.nlm.nih.gov/36515407/

3. Ye, Xiaomin, Zhong, Peiqu, Chen, Qiongfang, Zhang, Jiayuan, Zhao, Lijian. 2025. PFOS-Induced Perturbations in Trophoblast Functions through the Oip5os1/miR-155/Rnd3 Axis in PE. In Chemical research in toxicology, 38, 236-251. doi:10.1021/acs.chemrestox.4c00184. https://pubmed.ncbi.nlm.nih.gov/39807729/

4. Wooten, Serena, Smith, Keriayn N. . Long non-coding RNA OIP5-AS1 (Cyrano): A context-specific regulator of normal and disease processes. In Clinical and translational medicine, 12, e706. doi:10.1002/ctm2.706. https://pubmed.ncbi.nlm.nih.gov/35040588/