Mfsd10-KO Mouse

Mfsd10, a member of the major facilitator superfamily, is an eosinophil-specific cell surface molecule. It may be involved in maintaining cellular homeostasis as it belongs to a superfamily of transporters that move substances across lipid membranes [4]. Its role in diseases is of particular interest, especially in relation to eosinophil-related disorders [1,2].

In studies, monoclonal antibodies against Mfsd10 were developed. Administration of an anti-Mfsd10 monoclonal antibody (M2) significantly suppressed antigen-induced lung eosinophil infiltration in both ovalbumin-immunized and Th2 cell-transferred mice, similar to anti-Siglec-F. This indicates that Mfsd10 could be an effective target for treating eosinophil-related disorders such as bronchial asthma [1]. Also, Mfsd10 expression levels were found to be decreased with elevated or depleted energy consumption, suggesting its potential role in energy-related processes [3].

In conclusion, Mfsd10 is an eosinophil-specific molecule that has potential implications in treating eosinophil-related disorders like bronchial asthma. The use of monoclonal antibodies against it in in vivo models has demonstrated its role in suppressing eosinophil-mediated inflammation. Additionally, its expression changes in relation to energy consumption imply a role in energy-related biological processes [1,3].

References:

1. Nishimura, Tomoe, Saeki, Mayumi, Motoi, Yuji, Kaminuma, Osamu, Hiroi, Takachika. . Selective suppression of Th2 cell-mediated lung eosinophilic inflammation by anti-major facilitator super family domain containing 10 monoclonal antibody. In Allergology international : official journal of the Japanese Society of Allergology, 63 Suppl 1, 29-35. doi:10.2332/allergolint.13-OA-0635. https://pubmed.ncbi.nlm.nih.gov/24809373/

2. Motoi, Yuji, Saeki, Mayumi, Nishimura, Tomoe, Kaminuma, Osamu, Hiroi, Takachika. 2012. Establishment of monoclonal antibodies against a novel eosinophil-specific cell surface molecule, major facilitator super family domain containing 10. In Immunology letters, 147, 80-4. doi:10.1016/j.imlet.2012.07.001. https://pubmed.ncbi.nlm.nih.gov/22820041/

3. Bagchi, Sonchita, Perland, Emelie, Hosseini, Kimia, Kheder, Sania, Fredriksson, Robert. 2020. Probable role for major facilitator superfamily domain containing 6 (MFSD6) in the brain during variable energy consumption. In The International journal of neuroscience, 130, 476-489. doi:10.1080/00207454.2019.1694020. https://pubmed.ncbi.nlm.nih.gov/31906755/

4. Sreedharan, Smitha, Stephansson, Olga, Schiöth, Helgi B, Fredriksson, Robert. 2010. Long evolutionary conservation and considerable tissue specificity of several atypical solute carrier transporters. In Gene, 478, 11-8. doi:10.1016/j.gene.2010.10.011. https://pubmed.ncbi.nlm.nih.gov/21044875/