Cfap90-KO Mouse

Cfap90, information about its key aliases, associated pathways, and core functions is currently scarce based on the provided reference. However, it is one of the genes predominantly expressed in the mouse testis [1].

In a study using the CRISPR/Cas9 system to generate knockout mice for 12 testis-enriched genes, including Cfap90, it was found that the individual disruption of these genes did not affect male fertility. Mating tests revealed that Cfap90 knockout mice did not show any impairment in male fertility, indicating that this gene is not individually essential for male fertilization [1].

In conclusion, while Cfap90 is expressed predominantly in the mouse testis, its individual knockout does not impact male fertility, suggesting that it may not be a sole determinant in male infertility or a potential contraceptive target. The use of Cfap90 knockout mouse models in this study provided insights into the non-essential role of this gene in male fertility [1].

References:

1. Suzuki, Akira, Yabuta, Norikazu, Shimada, Keisuke, Matzuk, Martin M, Ikawa, Masahito. 2024. Individual disruption of 12 testis-enriched genes via the CRISPR/Cas9 system does not affect the fertility of male mice. In Journal of reproductive immunology, 163, 104252. doi:10.1016/j.jri.2024.104252. https://pubmed.ncbi.nlm.nih.gov/38697008/