Ccdc81-KO Mouse

Ccdc81, also known as coiled-coil domain containing 81, has been implicated in multiple biological processes. Evidence suggests it may play a role in protein-protein interaction in centrosome organization and could potentially function as a cargo-binding protein in association with Dynein-VII [1]. It is also related to the HU/IHF superfamily, which has diverse functions in DNA-structuring and genome maintenance in different organisms [1].

In a proteomic analysis of mammalian sperm cells, Ccdc81 was identified as a centrosome-associated protein, indicating its possible importance in centrosome-related functions [3]. In a study on triploid Pacific oyster sterility, piRNAs potentially interact with the Ccdc81 gene, suggesting a role in spermatogenesis regulation [4]. In bioinformatics analysis for nasopharyngeal carcinoma, Ccdc81 was identified as one of the hub genes, which may be regarded as a diagnostic biomarker [5]. In a prognostic model for early-stage lung adenocarcinoma, Ccdc81 was among the methylation driver genes used to build a model for predicting patient survival risk [2].

In conclusion, Ccdc81 appears to be involved in centrosome-related functions, spermatogenesis in oysters, and may serve as a biomarker in diseases such as nasopharyngeal carcinoma and early-stage lung adenocarcinoma. These findings from various research models contribute to understanding its biological functions and its potential significance in disease diagnosis and prognosis.

References:

1. Burroughs, A Maxwell, Kaur, Gurmeet, Zhang, Dapeng, Aravind, L. 2017. Novel clades of the HU/IHF superfamily point to unexpected roles in the eukaryotic centrosome, chromosome partitioning, and biologic conflicts. In Cell cycle (Georgetown, Tex.), 16, 1093-1103. doi:10.1080/15384101.2017.1315494. https://pubmed.ncbi.nlm.nih.gov/28441108/

2. Ren, Jin, Yang, Yun, Li, Chuanyin, Qin, Xiong, Zhang, Menghuan. 2021. A Novel Prognostic Model of Early-Stage Lung Adenocarcinoma Integrating Methylation and Immune Biomarkers. In Frontiers in genetics, 11, 634634. doi:10.3389/fgene.2020.634634. https://pubmed.ncbi.nlm.nih.gov/33552145/

3. Firat-Karalar, Elif N, Sante, Joshua, Elliott, Sarah, Stearns, Tim. 2014. Proteomic analysis of mammalian sperm cells identifies new components of the centrosome. In Journal of cell science, 127, 4128-33. doi:10.1242/jcs.157008. https://pubmed.ncbi.nlm.nih.gov/25074808/

4. Zhou, Yaru, Yu, Hong, Li, Qi, Liu, Shikai, Xu, Chengxun. 2024. Characterization of piRNAs in Diploid and Triploid Pacific Oyster Gonads: Exploring Their Potential Roles in Triploid Sterility. In Marine biotechnology (New York, N.Y.), 26, 1017-1029. doi:10.1007/s10126-024-10351-7. https://pubmed.ncbi.nlm.nih.gov/39073646/

5. Zhang, Ji-Zhou, Wu, Zeng-Hong, Cheng, Qing. . Screening and identification of key biomarkers in nasopharyngeal carcinoma: Evidence from bioinformatic analysis. In Medicine, 98, e17997. doi:10.1097/MD.0000000000017997. https://pubmed.ncbi.nlm.nih.gov/31770211/