Mtfr2-KO Mouse
一般名
Mtfr2-KO
製品ID
S-KO-13685
背景情報
C57BL/6JCya
系統ID
KOCMP-71804-Mtfr2-B6J-VA
状況
このマウス系統を論文で使用する場合は、「Mtfr2-KO Mouse（カタログ番号S-KO-13685）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Mtfr2-KO
系統ID
KOCMP-71804-Mtfr2-B6J-VA
遺伝子名
製品ID
S-KO-13685
遺伝子別名
Dufd1, Fam54a, 2610016C23Rik, 4933412C16Rik
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 10
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000169712
NCBIトランスクリプトID
NM_027930
ターゲット領域
Exon 3~5
有効領域の大きさ
~2.1 kb
遺伝子研究の概要
MTFR2, short for Mitochondrial fission regulator 2, belongs to the MTFR1 family and is crucial for regulating mitochondrial fission. It is also involved in metabolic reprogramming, particularly the shift from oxidative phosphorylation to glycolysis. MTFR2-related pathways include the Akt signaling pathway, and it is associated with important biological processes such as cancer-immunity cycle [2,3,4,7].
In hepatocellular carcinoma (HCC), MTFR2-dependent mitochondrial fission promotes HCC progression. Patients with heightened mitochondrial fission due to up-regulated MTFR2 have a worse prognosis. Down-regulation of MTFR2 in HCC cells blocks malignant behaviors, epithelial-to-mesenchymal transition (EMT), and glycolysis [1,3]. In oral squamous carcinoma, MTFR2 promotes cell proliferation, migration, and invasion by switching OXPHOS to glycolysis [4]. In lung adenocarcinoma, knockdown of MTFR2 inhibits cell proliferation, migration, and invasion via AKT-cyclin D1 signaling and EMT pathways [5]. In gastric cancer, down-regulation of MTFR2 inhibits the proliferation, migration, and invasion of GC cells in vitro and in vivo [6]. In breast cancer, knockdown of MTFR2 reduces the capacity for migration and invasion, and MTFR2 can switch glucose metabolism from OXPHS to glycolysis in a HIF1α-and HIF2α-dependent manner [7]. In endometrial carcinoma, MTFR2 promotes cell proliferation and growth through the miR-132-3p/PI3K/Akt signaling pathway [8].
In conclusion, MTFR2 plays a significant role in promoting the progression of multiple cancers, mainly through regulating mitochondrial fission and metabolic reprogramming. Loss-of-function experiments in various cancer cell lines have revealed its importance in processes like cell proliferation, migration, invasion, and metabolic shifts. Understanding MTFR2 provides potential targets for cancer therapy.
References:
1. Zhang, La, Zhang, Xiuzhen, Liu, Haichuan, Zhou, Baoyong, Jiang, Ning. 2024. MTFR2-dependent mitochondrial fission promotes HCC progression. In Journal of translational medicine, 22, 73. doi:10.1186/s12967-023-04845-6. https://pubmed.ncbi.nlm.nih.gov/38238834/
2. Huang, Qiaoqiao, Han, Ying, Shen, Edward, Cai, Changjing, Shen, Hong. 2022. MTFR2 shapes a barrier of immune microenvironment in hepatocellular carcinoma. In iScience, 26, 105095. doi:10.1016/j.isci.2022.105095. https://pubmed.ncbi.nlm.nih.gov/36713263/
3. Bao, Zhongming, Yang, Ming, Guo, Yunhu, Ge, Qi, Zhang, Huaguo. 2024. MTFR2 accelerates hepatocellular carcinoma mediated by metabolic reprogramming via the Akt signaling pathway. In Cellular signalling, 123, 111366. doi:10.1016/j.cellsig.2024.111366. https://pubmed.ncbi.nlm.nih.gov/39182591/
4. Wang, Wei, Xiong, Meihua, Jiang, Lin, Chen, Zean, Shao, Yisen. 2020. MTFR2 Promotes the Proliferation, Migration, and Invasion of Oral Squamous Carcinoma by Switching OXPHOS to Glycolysis. In Frontiers in oncology, 10, 858. doi:10.3389/fonc.2020.00858. https://pubmed.ncbi.nlm.nih.gov/32537437/
5. Lian, Zengzhi, Pang, Pei, Zhu, Yan, Du, Wenwen, Zhou, Jintao. 2022. Prognostic Value and Potential Mechanism of MTFR2 in Lung Adenocarcinoma. In Frontiers in oncology, 12, 832517. doi:10.3389/fonc.2022.832517. https://pubmed.ncbi.nlm.nih.gov/35600359/
6. Zhu, Hai, Wang, Gang, Zhu, Haixing, Xu, Aman. 2021. MTFR2, A Potential Biomarker for Prognosis and Immune Infiltrates, Promotes Progression of Gastric Cancer Based on Bioinformatics Analysis and Experiments. In Journal of Cancer, 12, 3611-3625. doi:10.7150/jca.58158. https://pubmed.ncbi.nlm.nih.gov/33995638/
7. Lu, Guanming, Lai, Yuanhui, Wang, Tiantian, Liu, Ruilei, Li, Jie. 2019. Mitochondrial fission regulator 2 (MTFR2) promotes growth, migration, invasion and tumour progression in breast cancer cells. In Aging, 11, 10203-10219. doi:10.18632/aging.102442. https://pubmed.ncbi.nlm.nih.gov/31740625/
8. Niu, Zhijun, Zhang, Yue, Wang, Yishan, Xu, Xia, Li, Lei. 2025. MTFR2 promotes endometrial carcinoma cell proliferation and growth via the miR-132-3p/PI3K/Akt signaling pathway. In Frontiers in medicine, 11, 1505071. doi:10.3389/fmed.2024.1505071. https://pubmed.ncbi.nlm.nih.gov/40129972/
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精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
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SPF対応地域:
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