Mpped2-KO Mouse
一般名
Mpped2-KO
製品ID
S-KO-15007
背景情報
C57BL/6NCya
系統ID
KOCMP-77015-Mpped2-B6N-VA
状況
このマウス系統を論文で使用する場合は、「Mpped2-KO Mouse（カタログ番号S-KO-15007）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Mpped2-KO
系統ID
KOCMP-77015-Mpped2-B6N-VA
遺伝子名
製品ID
S-KO-15007
遺伝子別名
239Fb, 2700082O15Rik
遺伝子別名
C57BL/6NCya
NCBI ID
修正
Conventional knockout
染色体
Chr 2
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000111063
NCBIトランスクリプトID
NM_001143683
ターゲット領域
Exon 3
有効領域の大きさ
~0.2 kb
遺伝子研究の概要
MPPED2, the Metallophosphoesterase-domain-containing protein 2, encodes a metallophosphodiesterase protein conserved throughout evolution. While its exact associated pathways are not fully elaborated in the provided abstracts, its role in various biological processes is emerging. It has potential importance in understanding the molecular mechanisms underlying different diseases [1,5,7].
MPPED2 expression is downregulated in several malignancies such as glioblastoma, breast cancer, and colorectal cancer, likely due to promoter hypermethylation. In glioblastoma, restoring MPPED2 expression inhibits cell proliferation, migration, and enhances sensitivity to temozolomide [1]. In breast cancer, its restoration reduces cell proliferation, migration, and invasion [5]. In neuroblastoma, Mpped2 overexpression in mice improves survival rate, impairs tumor growth, and induces neuronal differentiation, indicating its tumor-suppressing function [7]. Also, in trauma survivors, the rs2065418 TT SNP in MPPED2 is associated with altered systemic inflammation and adverse outcomes [3]. In addition, in a Chinese hypertensive cohort, the rs10767873 variant of MPPED2 is associated with kidney function and risk of cardiovascular disease [6]. In migraine, MPPED2 has a subtype-specific risk allele [2]. And in dental caries, MPPED2 (rs11031093, G Allele) is marginally associated with caries susceptibility in primary dentition [4].
In conclusion, MPPED2 appears to function as a potential tumor suppressor in multiple cancer types, influencing cell proliferation, migration, and drug sensitivity. Its role extends to other conditions such as trauma-related systemic inflammation, kidney function and cardiovascular disease in hypertension, and migraine. The study of MPPED2 through various genetic models helps in understanding the biological mechanisms underlying these diseases, potentially providing new therapeutic strategies.
References:
1. Pellecchia, Simona, De Martino, Marco, Esposito, Francesco, Fusco, Alfredo, Pallante, Pierlorenzo. 2021. MPPED2 is downregulated in glioblastoma, and its restoration inhibits proliferation and increases the sensitivity to temozolomide of glioblastoma cells. In Cell cycle (Georgetown, Tex.), 20, 716-729. doi:10.1080/15384101.2021.1901042. https://pubmed.ncbi.nlm.nih.gov/33734003/
2. Hautakangas, Heidi, Winsvold, Bendik S, Ruotsalainen, Sanni E, Palotie, Aarno, Pirinen, Matti. 2022. Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles. In Nature genetics, 54, 152-160. doi:10.1038/s41588-021-00990-0. https://pubmed.ncbi.nlm.nih.gov/35115687/
3. Schimunek, Lukas, Namas, Rami A, Yin, Jinling, Billiar, Timothy R, Vodovotz, Yoram. 2019. MPPED2 Polymorphism Is Associated With Altered Systemic Inflammation and Adverse Trauma Outcomes. In Frontiers in genetics, 10, 1115. doi:10.3389/fgene.2019.01115. https://pubmed.ncbi.nlm.nih.gov/31781170/
4. Katifelis, Hector, Sioziou, Anna, Gazouli, Maria, Emmanouil, Dimitris. 2020. ACTN2 (rs6656267) and MPPED2 (rs11031093 and rs536007) polymorphisms in primary dentition caries: A case-control study. In International journal of paediatric dentistry, 30, 478-482. doi:10.1111/ipd.12627. https://pubmed.ncbi.nlm.nih.gov/32040219/
5. Pellecchia, Simona, Sepe, Romina, Federico, Antonella, Fusco, Alfredo, Pallante, Pierlorenzo. 2019. The Metallophosphoesterase-Domain-Containing Protein 2 (MPPED2) Gene Acts as Tumor Suppressor in Breast Cancer. In Cancers, 11, . doi:10.3390/cancers11060797. https://pubmed.ncbi.nlm.nih.gov/31181813/
6. Zhong, Yixuan, Wu, Yiyi, Yang, Yunyun, Zhang, Mei, Zhang, Weili. 2023. Association of MPPED2 gene variant rs10767873 with kidney function and risk of cardiovascular disease in patients with hypertension. In Journal of human genetics, 68, 393-398. doi:10.1038/s10038-022-01118-w. https://pubmed.ncbi.nlm.nih.gov/36797372/
7. Liguori, Lucia, Andolfo, Immacolata, de Antonellis, Paqualino, Iolascon, Achille, Zollo, Massimo. 2012. The metallophosphodiesterase Mpped2 impairs tumorigenesis in neuroblastoma. In Cell cycle (Georgetown, Tex.), 11, 569-81. doi:10.4161/cc.11.3.19063. https://pubmed.ncbi.nlm.nih.gov/22262177/
品質管理基準
精子検査
凍結前の精子濃度を測定し、精子の生存能力の判定します。
凍結後の精子では、各バッチから1本の凍結保存された精子を選び出し、体外受精に使用します。
環境基準:
SPF対応地域:
グローバル由来:
Cyagenお問い合わせ
カスタムの動物モデルに関するご相談は、下記のフォームにご記入いただき、ご連絡いただくか見積もりをご依頼ください。
Cyagenはお客様のプライバシーを大変重視しています。当社の最新の製品や情報をお届けしたいと思っています。お客様の設定をご確認ください。
これらの配信はいつでも解除できます。配信停止方法およびデータ保護の詳細は プライバシーポリシー をご確認ください。
以下のボタンをクリックすることで、このフォームにご入力いただいた個人情報をCyagenが保存・処理し、ご要望のコンテンツを提供することに同意されたことになります。