Rbbp7-KO Mouse

RBBP7, also known as retinoblastoma-binding protein 7, is a core component of many histone modification and chromatin remodeling complexes, regulating chromatin metabolism, which is crucial for DNA replication and cell proliferation [4,5,6]. It is involved in various signaling pathways such as PI3K/AKT, and plays important roles in multiple biological processes and disease conditions [1].

In mice, deprivation of rbbp7 in spermatogonial and pachytene spermatocyte-derived cells led to cell cycle arrest and apoptosis, indicating its importance in spermatogenesis [2]. In uterine stromal cells, Rbbp7 silencing compromised decidualization via attenuating histone H4 acetylation and cyclin D3 expression, suggesting it is required for normal postimplantation decidual development [5].

In conclusion, RBBP7 is essential for normal cellular functions related to chromatin modification, cell cycle regulation, and proliferation. Its role has been clearly demonstrated in mouse models in spermatogenesis and uterine decidualization. In diseases, it has been associated with cancers like hepatocellular carcinoma, esophageal cancer, and testicular tumors, where it promotes tumor progression, highlighting its potential as a biomarker and therapeutic target [1,2,3,6].

References:

1. Fang, Yuan, Tang, WeiQiang, Qu, Siming, Zeng, Zhong, Huang, HanFei. 2024. RBBP7, regulated by SP1, enhances the Warburg effect to facilitate the proliferation of hepatocellular carcinoma cells via PI3K/AKT signaling. In Journal of translational medicine, 22, 170. doi:10.1186/s12967-024-04964-8. https://pubmed.ncbi.nlm.nih.gov/38368381/

2. Li, Jingping, Zheng, Huimei, Hou, Jiaru, Jin, Fan, Xi, Yongmei. 2023. X-linked RBBP7 mutation causes maturation arrest and testicular tumors. In The Journal of clinical investigation, 133, . doi:10.1172/JCI171541. https://pubmed.ncbi.nlm.nih.gov/37843278/

3. Wang, Renfeng, Huang, Zhiliang, Lin, Zhenyang, Du, Chaoxiang, Fan, Hong. . Hypoxia-induced RBBP7 promotes esophagus cancer progression by inducing CDK4 expression. In Acta biochimica et biophysica Sinica, 54, 179-186. doi:10.3724/abbs.2021027. https://pubmed.ncbi.nlm.nih.gov/35538026/

4. Wang, Yicun, Wang, Yuxuan, Zhang, Di, Wang, Wei, Hu, Xiaopeng. 2022. Identifying RBBP7 as a Promising Diagnostic Biomarker for BK Virus-Associated Nephropathy. In Journal of immunology research, 2022, 6934744. doi:10.1155/2022/6934744. https://pubmed.ncbi.nlm.nih.gov/35958876/

5. He, Hui, Kong, Shuangbo, Liu, Fei, Wang, Haibin, Huo, Ran. 2015. Rbbp7 Is Required for Uterine Stromal Decidualization in Mice. In Biology of reproduction, 93, 13. doi:10.1095/biolreprod.115.129015. https://pubmed.ncbi.nlm.nih.gov/26040671/

6. Yu, Ning, Zhang, Peng, Wang, Li, Yang, Shanshan, Lu, Haijun. 2018. RBBP7 is a prognostic biomarker in patients with esophageal squamous cell carcinoma. In Oncology letters, 16, 7204-7211. doi:10.3892/ol.2018.9543. https://pubmed.ncbi.nlm.nih.gov/30546458/