BC048562-KO Mouse

BC048562 is a gene whose function was previously less well-known. Through gene-targeted screens, it has been found to potentially be involved in pathways related to nociception. Nociception is the neural process of encoding noxious stimuli, and understanding genes like BC048562 can be crucial for uncovering the genetic mechanisms underlying pain perception [1].

In a large-scale gene-targeted screen involving 110 single-gene knockout mouse strains, the BC048562 knockout mouse strain was among 13 identified with altered nocifensive behavior in one or more nociception and hypersensitivity assays. These assays included chemical nociception (formalin), mechanical and thermal nociception (von Frey filaments and Hargreaves tests), with or without an inflammatory agent (complete Freund's adjuvant). This indicates that BC048562 plays a role in nociception, potentially revealing novel pathways involved in inflammatory pain [1].

In conclusion, BC048562 is a gene that has been shown through knockout mouse models to be involved in nociception pathways. The BC048562 KO mouse model provides valuable insights into the genetic mechanisms of inflammatory pain, which may contribute to understanding the disease better and could potentially serve as a model for therapeutic target validation and drug development in the area of pain management [1].

References:

1. Wotton, Janine M, Peterson, Emma, Flenniken, Ann M, Mandillo, Silvia, White, Jacqueline K. 2021. Identifying genetic determinants of inflammatory pain in mice using a large-scale gene-targeted screen. In Pain, 163, 1139-1157. doi:10.1097/j.pain.0000000000002481. https://pubmed.ncbi.nlm.nih.gov/35552317/