Ccdc70-KO Mouse

Ccdc70, which encodes coiled-coil domain-containing protein 70, is associated with spermatogenesis. Although no specific pathways are clearly detailed in the given references, its high expression in the testis indicates its importance in male reproductive biology. Genetic models, such as mouse models, can be valuable for further exploring its function [1,2].

In mice, the Ccdc70 gene is highly expressed in the testis, with low expression in the epididymis. The Ccdc70 protein is mainly present in spermatocytes, round spermatids of the testis, and epithelial cells of the epididymis. Bioinformatics analysis shows a conserved structural domain in mammalian evolution, suggesting its conserved function. In Duroc pigs, CCDC70 is identified as a candidate gene related to semen traits, including sperm motility, progressive motility, sperm abnormality rate, and total sperm count [1,2].

In conclusion, Ccdc70 is essential for spermatogenesis and epididymal sperm maturation in mice, and may have a role in determining semen traits in pigs. Studies in these genetic models contribute to understanding its function in male reproductive processes, potentially providing insights into male infertility and related diseases [1,2].

References:

1. Chen, Jian-bo, Zheng, Wen-zhong, Li, Yu-chi, Jiang, Zhi-mao, Gui, Yao-ting. . [Expression characteristics of the Ccdc70 gene in the mouse testis during spermatogenesis]. In Zhonghua nan ke xue = National journal of andrology, 22, 12-6. doi:. https://pubmed.ncbi.nlm.nih.gov/26931019/

2. Zhang, Xiaoke, Lin, Qing, Liao, Weili, Huang, Xiang, Zhang, Hao. 2023. Identification of New Candidate Genes Related to Semen Traits in Duroc Pigs through Weighted Single-Step GWAS. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13030365. https://pubmed.ncbi.nlm.nih.gov/36766254/