Sec11c-KO Mouse

Sec11c is a gene associated with the endoplasmic reticulum membrane. It is part of the signal peptidase complex (SPC) in the endoplasmic reticulum, which is crucial for removing signal peptides from secretory pre-proteins [1]. The SPC exists in two functional paralogs with distinct proteolytic subunits, and Sec11c may contribute to the function of this complex in specific cell processes.

In the context of human diseases, Sec11c has been implicated in several conditions. In lung adenocarcinoma, it was included in a 6-gene prognostic risk score model related to T-cell mediated cell killing, which can help screen the prognosis of patients and those sensitive to immunotherapy [2]. In parathyroid adenoma, differential gene expression analysis has suggested that Sec11c, along with other genes, may be important factors contributing to the development of this disease [3,4]. In pigs, Sec11c was identified as a candidate gene associated with growth and metabolism traits [5], as well as lipid biosynthesis and fatty acid composition, indicating its potential role in animal growth-related biological processes [6]. Additionally, in colon cancer cells treated with PSP205, Sec11c was among the genes with transcriptional upregulation related to ER-stress response [7].

In conclusion, Sec11c plays an important role in multiple biological processes, especially those related to the endoplasmic reticulum's function in protein processing. Its implications in various diseases like lung adenocarcinoma, parathyroid adenoma, and potentially in colon cancer, as well as its association with growth and lipid-related traits in pigs, highlight its significance in both human health and animal biology research.

References:

1. Liaci, A Manuel, Steigenberger, Barbara, Telles de Souza, Paulo Cesar, Scheltema, Richard A, Förster, Friedrich. 2021. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. In Molecular cell, 81, 3934-3948.e11. doi:10.1016/j.molcel.2021.07.031. https://pubmed.ncbi.nlm.nih.gov/34388369/

2. Bi, Lei, Ai, Cheng, Zhang, Hong, Xiong, Jing, Lv, Zhongzhu. . Prognostic characteristics of T-cell mediated cell killing-related genes in lung adenocarcinoma. In Autoimmunity, 56, 2250097. doi:10.1080/08916934.2023.2250097. https://pubmed.ncbi.nlm.nih.gov/37624966/

3. Kim, Sang Wan. 2022. Gene expression profiles in parathyroid adenoma and normal parathyroid tissue. In Vitamins and hormones, 120, 289-304. doi:10.1016/bs.vh.2022.04.003. https://pubmed.ncbi.nlm.nih.gov/35953114/

4. Chai, Young Jun, Chae, Heejoon, Kim, Kwangsoo, Lee, Kyu Eun, Kim, Sang Wan. 2019. Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue. In Journal of clinical medicine, 8, . doi:10.3390/jcm8030297. https://pubmed.ncbi.nlm.nih.gov/30832348/

5. Tang, Zhenshuang, Xu, Jingya, Yin, Lilin, Zhao, Shuhong, Liu, Xiaolei. 2019. Genome-Wide Association Study Reveals Candidate Genes for Growth Relevant Traits in Pigs. In Frontiers in genetics, 10, 302. doi:10.3389/fgene.2019.00302. https://pubmed.ncbi.nlm.nih.gov/31024621/

6. Ma, Fuping, Zou, Quan, Zhao, Xitong, Ding, Xiangdong, Wang, Chuduan. 2025. Multi-omics integration reveals the regulatory mechanisms of APC and CREB5 genes in lipid biosynthesis and fatty acid composition in pigs. In Food chemistry, 482, 143999. doi:10.1016/j.foodchem.2025.143999. https://pubmed.ncbi.nlm.nih.gov/40187300/

7. Samanta, Soma, Roy, Joyeeta, Debnath, Bikash, Ljungman, Mats, Neamati, Nouri. 2025. PSP205, a Novel Phenyl Sulfonyl Piperidine, Induces Apoptotic Cell Death in Colon Cancer by Modulating Coat Protein Complex-Mediated Vesicle Trafficking. In ACS pharmacology & translational science, 8, 1072-1086. doi:10.1021/acsptsci.4c00617. https://pubmed.ncbi.nlm.nih.gov/40242573/