Meltf-KO Mouse

MELTF, also known as melanotransferrin, MFI2, or CD228, is a gene with diverse functions. It is involved in processes like endometrial regeneration, where it may regulate ferroptosis, pyroptosis, and autophagy [3]. In cancer, it has been implicated in the progression of lung adenocarcinoma, potentially via the Notch signaling pathway [2]. Additionally, its expression is associated with various cancers, suggesting its role in tumor-related biological processes [4,6].

In osteosarcoma, the lncRNA MELTF-AS1, which may be related to MELTF, acts as a pro-metastasis gene by upregulating MMP14 [1]. In non-small cell lung cancer, MELTF-AS1 also promotes tumorigenesis by driving phase separation of YBX1 to activate ANXA8 [5]. In lung adenocarcinoma, E2F1 activates MELTF to promote cancer progression through the Notch signaling pathway [2].

In conclusion, MELTF plays important roles in endometrial regeneration and cancer progression, especially in lung adenocarcinoma and osteosarcoma. Research on MELTF and its related lncRNAs, like MELTF-AS1, provides insights into the biological mechanisms of these processes, which may help in developing new diagnostic and therapeutic strategies for related diseases.

References:

1. Ding, Lei, Liu, Taiyuan, Qu, Yuan, Ge, Wanbao, Zhang, Shanyong. 2021. lncRNA MELTF-AS1 facilitates osteosarcoma metastasis by modulating MMP14 expression. In Molecular therapy. Nucleic acids, 26, 787-797. doi:10.1016/j.omtn.2021.08.022. https://pubmed.ncbi.nlm.nih.gov/34729248/

2. Zhang, Lidan, Shi, Lei. 2023. The E2F1/MELTF axis fosters the progression of lung adenocarcinoma by regulating the Notch signaling pathway. In Mutation research, 827, 111837. doi:10.1016/j.mrfmmm.2023.111837. https://pubmed.ncbi.nlm.nih.gov/37820570/

3. Mao, Yanhong, Wang, Mei, Xiong, Yao, Ma, Ling, Zhang, Yuanzhen. 2022. MELTF Might Regulate Ferroptosis, Pyroptosis, and Autophagy in Platelet-Rich Plasma-Mediated Endometrial Epithelium Regeneration. In Reproductive sciences (Thousand Oaks, Calif.), 30, 1506-1520. doi:10.1007/s43032-022-01101-y. https://pubmed.ncbi.nlm.nih.gov/36303086/

4. Shu, Jianfeng, Jiang, Jinni, Zhao, Guofang. 2023. Identification of novel gene signature for lung adenocarcinoma by machine learning to predict immunotherapy and prognosis. In Frontiers in immunology, 14, 1177847. doi:10.3389/fimmu.2023.1177847. https://pubmed.ncbi.nlm.nih.gov/37583701/

5. Lu, Xiyi, Wang, Jing, Wang, Wei, Guo, Renhua, Zhang, Erbao. 2022. Copy number amplification and SP1-activated lncRNA MELTF-AS1 regulates tumorigenesis by driving phase separation of YBX1 to activate ANXA8 in non-small cell lung cancer. In Oncogene, 41, 3222-3238. doi:10.1038/s41388-022-02292-z. https://pubmed.ncbi.nlm.nih.gov/35508543/

6. Mazahreh, Rebecca, Mason, Marsha L, Gosink, John J, Lewis, Timothy S, Sandall, Sharsti. . SGN-CD228A Is an Investigational CD228-Directed Antibody-Drug Conjugate with Potent Antitumor Activity across a Wide Spectrum of Preclinical Solid Tumor Models. In Molecular cancer therapeutics, 22, 421-434. doi:10.1158/1535-7163.MCT-22-0401. https://pubmed.ncbi.nlm.nih.gov/36800443/