Crabp2-KO Mouse
一般名
Crabp2-KO
製品ID
S-KO-17504
背景情報
C57BL/6JCya
系統ID
KOCMP-12904-Crabp2-B6J-VB
状況
このマウス系統を論文で使用する場合は、「Crabp2-KO Mouse（カタログ番号S-KO-17504）はサイアジェンから購入しました。」と引用してください。
製品タイプ
年齢
遺伝子型
性別
数量
標準的な配送方法では、少なくとも3匹のヘテロ接合体キャリアを保証しています。ホモ接合体キャリアや指定された性別の個体の繁殖サービスも利用可能です。
基本情報
系統名
Crabp2-KO
系統ID
KOCMP-12904-Crabp2-B6J-VB
遺伝子名
製品ID
S-KO-17504
遺伝子別名
Crabp-2, CrabpII
遺伝子別名
C57BL/6JCya
NCBI ID
修正
Conventional knockout
染色体
Chr 3
表現型
アプリケーション
--
さらに
系統詳細
EnsemblトランスクリプトID
ENSMUST00000005019
NCBIトランスクリプトID
NM_007759
ターゲット領域
Exon 2~4
有効領域の大きさ
~1.3 kb
遺伝子研究の概要
CRABP2, Cellular retinoic acid - binding protein 2, is involved in retinoid partitioning between different nuclear receptors. It is associated with multiple biological processes and signaling pathways, such as the Wnt/β - catenin, integrin/FAK/AKT, and PI3K/Akt pathways [3,4,7]. Its function is vital in various physiological and pathological conditions, and genetic models are useful for studying its role.
In cancer research, CRABP2 shows diverse effects. In melanoma, high levels of CRABP2 predict poor prognosis in patients treated with PD - 1 inhibitors, and it may regulate immunotherapy by influencing cancer - associated fibroblasts infiltration [1]. In endometrial cancer, high CRABP2 expression is linked to serous EC, reduced overall survival, advanced stage and grade [2]. In thyroid cancer, it is associated with recurrence and promotes invasion via the integrin/FAK/AKT pathway [4]. In lung cancer, it promotes metastasis via HuR and integrin β1/FAK/ERK signaling [5]. In serous ovarian cancer, it accelerates epithelial - mesenchymal transition by promoting TRIM16 methylation via upregulating EZH2 expression [6]. In prostate cancer, it promotes cell migration and invasion by activating PI3K/AKT and MAPK signalling pathways via upregulating LAMB3 [8]. In breast cancer, it functions as an oncogene promoting tumour cell proliferation, migration, and invasion [9]. In dermal papilla cells of Hu sheep, it promotes proliferation via the Wnt/β - catenin pathway [3]. In human osteoblast cells, overexpression of CRABP2 inhibits dexamethasone - induced apoptosis [7].
In conclusion, CRABP2 is involved in multiple biological processes, especially in cancer - related events such as tumorigenesis, metastasis, and immune response regulation. Research on CRABP2 using gene knockout or conditional knockout mouse models (not explicitly mentioned in the given references but generally applicable for gene function studies) could potentially further clarify its role in these disease conditions, providing insights for developing targeted therapies.
References：
1. Zeng, Shuangshuang, Chen, X I, Yi, Qiaoli, Yan, Yuanliang, Liu, Shao. 2023. CRABP2 regulates infiltration of cancer-associated fibroblasts and immune response in melanoma. In Oncology research, 32, 261-272. doi:10.32604/or.2023.042345. https://pubmed.ncbi.nlm.nih.gov/38186580/
2. Egan, Donagh, Moran, Bruce, Wilkinson, Michael, le Roux, Carel W, Brennan, Donal J. 2022. CRABP2 - A novel biomarker for high-risk endometrial cancer. In Gynecologic oncology, 167, 314-322. doi:10.1016/j.ygyno.2022.09.020. https://pubmed.ncbi.nlm.nih.gov/36163055/
3. He, Mingliang, Lv, Xiaoyang, Cao, Xiukai, Wang, Shanhe, Sun, Wei. 2023. CRABP2 Promotes the Proliferation of Dermal Papilla Cells via the Wnt/β-Catenin Pathway. In Animals : an open access journal from MDPI, 13, . doi:10.3390/ani13122033. https://pubmed.ncbi.nlm.nih.gov/37370543/
4. Liu, Chien-Liang, Hsu, Yi-Chiung, Kuo, Chi-Yu, Li, Ying-Syuan, Cheng, Shih-Ping. . CRABP2 Is Associated With Thyroid Cancer Recurrence and Promotes Invasion via the Integrin/FAK/AKT Pathway. In Endocrinology, 163, . doi:10.1210/endocr/bqac171. https://pubmed.ncbi.nlm.nih.gov/36240291/
5. Wu, Jun-I, Lin, Yi-Pei, Tseng, Chien-Wei, Chen, Hui-Jane, Wang, Lu-Hai. 2019. Crabp2 Promotes Metastasis of Lung Cancer Cells via HuR and Integrin β1/FAK/ERK Signaling. In Scientific reports, 9, 845. doi:10.1038/s41598-018-37443-4. https://pubmed.ncbi.nlm.nih.gov/30696915/
6. Xie, Tingting, Tan, Minghua, Gao, Yang, Yang, Hong. 2022. CRABP2 accelerates epithelial mesenchymal transition in serous ovarian cancer cells by promoting TRIM16 methylation via upregulating EZH2 expression. In Environmental toxicology, 37, 1957-1967. doi:10.1002/tox.23542. https://pubmed.ncbi.nlm.nih.gov/35442568/
7. Zhang, Haiping, Yu, Ziliang, Sun, Farui, Jin, Jin. 2021. Overexpression of CRABP2 inhibits dexamethasone-induced apoptosis in human osteoblast cells. In Journal of orthopaedic surgery and research, 16, 272. doi:10.1186/s13018-021-02386-6. https://pubmed.ncbi.nlm.nih.gov/33879199/
8. Wang, Rui, Liao, Zhaoping, Liu, Chunhua, Cheng, Gang, Li, Sanlian. . CRABP2 promotes cell migration and invasion by activating PI3K/AKT and MAPK signalling pathways via upregulating LAMB3 in prostate cancer. In Journal of biochemistry, 176, 313-324. doi:10.1093/jb/mvae052. https://pubmed.ncbi.nlm.nih.gov/39038078/
9. Mei, Jie, Cai, Yun, Chen, Lingyan, Pan, Xiang, Zhang, Yan. 2023. The heterogeneity of tumour immune microenvironment revealing the CRABP2/CD69 signature discriminates distinct clinical outcomes in breast cancer. In British journal of cancer, 129, 1645-1657. doi:10.1038/s41416-023-02432-6. https://pubmed.ncbi.nlm.nih.gov/37715025/
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