Slc7a8-KO Mouse

Slc7a8, encoding the L-type amino acid transporter 2 (LAT2), is a gene that plays a crucial role in amino acid transport. It is involved in the transportation of arginine, large amino acids, and L-DOPA [2,3]. This gene is associated with pathways related to cell metabolism, proliferation, and immune responses. Genetic models, such as knockout mouse models, have been valuable in studying its functions.

In a diet-induced obesity mouse model, Slc7a8 knockout (KO) mice gained significantly less weight than wild-type mice on a high-fat diet. KO mice also had reduced adipocyte mass, hypertrophy, and macrophage infiltration in adipose depots, along with decreased lipid accumulation in multiple organs, indicating that Slc7a8 deletion protects against diet-induced obesity [1]. In the context of type 2 innate lymphoid cells (ILC2), genetic ablation of Slc7a8 in lymphocytes reduced the frequency of ILC2s, suppressed cytokine production, and impaired type 2 immune responses, identifying Slc7a8 as a key amino acid supplier for ILC2 functions [2].

In summary, Slc7a8 is essential for amino acid-related metabolic processes. Its deletion in KO mouse models has revealed its role in protecting against diet-induced obesity and in maintaining ILC2 functions. These findings contribute to our understanding of obesity-related diseases and immune-related conditions, highlighting the importance of Slc7a8 in these biological contexts.